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    Adar adenosine deaminase, RNA-specific [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81635, updated on 3-Dec-2024

    Summary

    Official Symbol
    Adarprovided by RGD
    Official Full Name
    adenosine deaminase, RNA-specificprovided by RGD
    Primary source
    RGD:71099
    See related
    EnsemblRapid:ENSRNOG00000020744 AllianceGenome:RGD:71099
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in several processes, including RNA metabolic process; negative regulation of protein kinase activity by regulation of protein phosphorylation; and nucleocytoplasmic transport. Predicted to act upstream of or within several processes, including hematopoietic stem cell homeostasis; hemopoiesis; and regulation of gene expression. Located in nuclear speck. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (adenosine deaminase RNA specific). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 163.5), Heart (RPKM 142.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Adar in Genome Data Viewer
    Location:
    2q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177436076..177475969)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175138391..175178280)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189045551..189085448)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphomevalonate kinase Neighboring gene potassium calcium-activated channel subfamily N member 3 Neighboring gene uncharacterized LOC134485639 Neighboring gene cholinergic receptor nicotinic beta 2 subunit Neighboring gene ubiquitin conjugating enzyme E2 Q1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded RNA adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA adenosine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in RISC complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within RISC complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenosine to inosine editing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adenosine to inosine editing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenosine to inosine editing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenosine to inosine editing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within base conversion or substitution editing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cellular response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within definitive hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hematopoietic stem cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of post-transcriptional gene silencing by regulatory ncRNA IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of post-transcriptional gene silencing by regulatory ncRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pre-miRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interferon-alpha IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interferon-alpha ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in somatic diversification of immune receptors via somatic mutation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within somatic diversification of immune receptors via somatic mutation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of supraspliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of supraspliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of supraspliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    double-stranded RNA-specific adenosine deaminase
    Names
    DRADA
    NP_112268.1
    XP_006232836.1
    XP_006232837.1
    XP_006232838.1
    XP_006232840.1
    XP_038959138.1
    XP_063138689.1
    XP_063138690.1
    XP_063138691.1
    XP_063138692.1
    XP_063138693.1
    XP_063138694.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031006.1NP_112268.1  double-stranded RNA-specific adenosine deaminase

      See identical proteins and their annotated locations for NP_112268.1

      Status: PROVISIONAL

      Source sequence(s)
      U18942
      UniProtKB/Swiss-Prot
      P55266
      UniProtKB/TrEMBL
      A6J6H2, G3V8T3
      Related
      ENSRNOP00000028181.2, ENSRNOT00000028181.7
      Conserved Domains (4) summary
      smart00358
      Location:454519
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7851168
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:137203
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:245309
      z-alpha; Adenosine deaminase z-alpha domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      177436076..177475969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282623.1XP_063138693.1  double-stranded RNA-specific adenosine deaminase isoform X7

    2. XM_063282621.1XP_063138691.1  double-stranded RNA-specific adenosine deaminase isoform X8

    3. XM_006232775.5XP_006232837.1  double-stranded RNA-specific adenosine deaminase isoform X2

      UniProtKB/TrEMBL
      A6J6H2, G3V8T3
      Conserved Domains (4) summary
      smart00358
      Location:462527
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7671150
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:145211
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:253317
      z-alpha; Adenosine deaminase z-alpha domain
    4. XM_039103210.2XP_038959138.1  double-stranded RNA-specific adenosine deaminase isoform X4

      UniProtKB/TrEMBL
      A6J6H2, G3V8T3
      Conserved Domains (6) summary
      smart00552
      Location:7541137
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:145211
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:253317
      z-alpha; Adenosine deaminase z-alpha domain
      cd19913
      Location:421491
      DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)
      cd19915
      Location:640710
      DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
      cl00054
      Location:532602
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
    5. XM_006232778.4XP_006232840.1  double-stranded RNA-specific adenosine deaminase isoform X7

      See identical proteins and their annotated locations for XP_006232840.1

      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:540923
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cl02659
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    6. XM_063282622.1XP_063138692.1  double-stranded RNA-specific adenosine deaminase isoform X9

    7. XM_006232774.5XP_006232836.1  double-stranded RNA-specific adenosine deaminase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEC1, A6J6H2, G3V8T3
      Related
      ENSRNOP00000090863.1, ENSRNOT00000093799.2
      Conserved Domains (4) summary
      smart00358
      Location:462527
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7931176
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:145211
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:253317
      z-alpha; Adenosine deaminase z-alpha domain
    8. XM_063282620.1XP_063138690.1  double-stranded RNA-specific adenosine deaminase isoform X6

      UniProtKB/TrEMBL
      A6J6H2, G3V8T3
    9. XM_006232776.5XP_006232838.1  double-stranded RNA-specific adenosine deaminase isoform X3

      UniProtKB/TrEMBL
      A6J6H2, G3V8T3
      Conserved Domains (4) summary
      smart00358
      Location:454519
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7591142
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:137203
      z-alpha; Adenosine deaminase z-alpha domain
      cl02659
      Location:245309
      z-alpha; Adenosine deaminase z-alpha domain
    10. XM_063282619.1XP_063138689.1  double-stranded RNA-specific adenosine deaminase isoform X5

      UniProtKB/TrEMBL
      A6J6H2, G3V8T3
    11. XM_063282624.1XP_063138694.1  double-stranded RNA-specific adenosine deaminase isoform X10

      UniProtKB/TrEMBL
      A6J6H3