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    Htr4 5-hydroxytryptamine receptor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25324, updated on 9-Dec-2024

    Summary

    Official Symbol
    Htr4provided by RGD
    Official Full Name
    5-hydroxytryptamine receptor 4provided by RGD
    Primary source
    RGD:2850
    See related
    EnsemblRapid:ENSRNOG00000019134 AllianceGenome:RGD:2850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables G protein-coupled serotonin receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and gamma-aminobutyric acid signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in several cellular components, including dendrite; glutamatergic synapse; and postsynapse. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 13.0), Kidney (RPKM 3.6) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Htr4 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (58036277..58221327)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (55765981..55949921)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (57637013..57820317)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556293 Neighboring gene adrenoceptor beta 2 Neighboring gene uncharacterized LOC108348797 Neighboring gene uncharacterized LOC120098287 Neighboring gene uncharacterized LOC134483040 Neighboring gene F-box protein 38 Neighboring gene serine protease inhibitor Kazal-type 9-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled serotonin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled serotonin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serotonin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating serotonin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating serotonin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cognition TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in large intestinal transit IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in large intestinal transit ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of gastrointestinal epithelium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of gastrointestinal epithelium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mucus secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mucus secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of appetite IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 4
    Names
    5 hydroxytryptamine ( serotonin) receptor 4
    5-HT-4
    5-HT4 receptor (two splicing variants L and S)
    5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
    serotonin receptor 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012853.2NP_036985.2  5-hydroxytryptamine receptor 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IXJ9, C4WYH2, F1LS47
      Related
      ENSRNOP00000106833.1, ENSRNOT00000168253.1
      Conserved Domains (1) summary
      cd15056
      Location:20323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      58036277..58221327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254793.5XP_006254855.1  5-hydroxytryptamine receptor 4 isoform X2

      See identical proteins and their annotated locations for XP_006254855.1

      UniProtKB/TrEMBL
      A0A140UHX7, A0A9K3Y826, A6IXJ7, C4WYH1, F1LM98
      Related
      ENSRNOP00000059569.5, ENSRNOT00000065483.6
      Conserved Domains (2) summary
      pfam00001
      Location:36312
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam05296
      Location:138329
      TAS2R; Taste receptor protein (TAS2R)
    2. XM_017600859.3XP_017456348.1  5-hydroxytryptamine receptor 4 isoform X1

      UniProtKB/TrEMBL
      A6IXJ9, C4WYH2, F1LS47
      Conserved Domains (1) summary
      cd15056
      Location:20323
      7tmA_5-HT4; serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors