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    Dlgap4 DLG associated protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286930, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dlgap4provided by RGD
    Official Full Name
    DLG associated protein 4provided by RGD
    Primary source
    RGD:708350
    See related
    EnsemblRapid:ENSRNOG00000020225 AllianceGenome:RGD:708350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dap4; DAP-4; SAPAP4
    Summary
    Enables protein domain specific binding activity. Predicted to be involved in modification of postsynaptic structure; modulation of chemical synaptic transmission; and regulation of synapse maturation. Located in dendrite and neuronal cell body. Orthologous to human DLGAP4 (DLG associated protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 89.3), Lung (RPKM 58.8) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dlgap4 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (165584271..165731868)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145124189..145271791)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (152752091..152846118)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101766 Neighboring gene uncharacterized LOC134486192 Neighboring gene uncharacterized LOC103691945 Neighboring gene uncharacterized LOC102551821 Neighboring gene myosin light chain 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in modification of postsynaptic structure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modification of postsynaptic structure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of synapse maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synapse maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cholinergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic specialization IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic specialization ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    disks large-associated protein 4
    Names
    PSD-95/SAP90-associated protein-4
    PSD-95/SAP90-binding protein 4
    SAP90/PSD-95-associated protein 4
    SAPAP-4
    discs, large homolog-associated protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429777.1NP_001416706.1  disks large-associated protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ACV4
    2. NM_001429778.1NP_001416707.1  disks large-associated protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    3. NM_001429779.1NP_001416708.1  disks large-associated protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    4. NM_001429780.1NP_001416709.1  disks large-associated protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    5. NM_001429781.1NP_001416710.1  disks large-associated protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    6. NM_173145.3NP_775168.2  disks large-associated protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P97839
      UniProtKB/TrEMBL
      A6KIB5, G3V927
      Related
      ENSRNOP00000034166.2, ENSRNOT00000037177.4
      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      165584271..165731868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283180.1XP_063139250.1  disks large-associated protein 4 isoform X3

    2. XM_063283179.1XP_063139249.1  disks large-associated protein 4 isoform X2

    3. XM_039104402.2XP_038960330.1  disks large-associated protein 4 isoform X1

      Related
      ENSRNOP00000090954.2, ENSRNOT00000100071.2
      Conserved Domains (1) summary
      pfam03359
      Location:647989
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    4. XM_039104406.2XP_038960334.1  disks large-associated protein 4 isoform X7

      Conserved Domains (1) summary
      pfam03359
      Location:17298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    5. XM_039104408.2XP_038960336.1  disks large-associated protein 4 isoform X8

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    6. XM_063283181.1XP_063139251.1  disks large-associated protein 4 isoform X6

    7. XM_039104405.2XP_038960333.1  disks large-associated protein 4 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A541
      Related
      ENSRNOP00000086332.1, ENSRNOT00000116081.2
      Conserved Domains (1) summary
      pfam03359
      Location:121453
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    8. XM_039104404.2XP_038960332.1  disks large-associated protein 4 isoform X4

      Conserved Domains (1) summary
      pfam03359
      Location:130462
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    9. XM_039104407.1XP_038960335.1  disks large-associated protein 4 isoform X7

      Conserved Domains (1) summary
      pfam03359
      Location:17298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    10. XM_039104410.2XP_038960338.1  disks large-associated protein 4 isoform X8

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein