U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Slc7a1 solute carrier family 7 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25648, updated on 3-Dec-2024

    Summary

    Official Symbol
    Slc7a1provided by RGD
    Official Full Name
    solute carrier family 7 member 1provided by RGD
    Primary source
    RGD:3716
    See related
    EnsemblRapid:ENSRNOG00000000924 AllianceGenome:RGD:3716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ERR; CAT1; EcoR; Atrc1; Cat-1
    Summary
    Enables L-arginine transmembrane transporter activity. Involved in L-arginine import across plasma membrane; L-arginine transmembrane transport; and regulation of TOR signaling. Located in apical plasma membrane and basal plasma membrane. Orthologous to human SLC7A1 (solute carrier family 7 member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 245.3), Brain (RPKM 67.3) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc7a1 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (11664488..11740030)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (6628288..6703849)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (8032775..8108972)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481151 Neighboring gene peptidylprolyl isomerase A, pseudogene 3 Neighboring gene microtubule associated scaffold protein 2 Neighboring gene uncharacterized LOC102547400 Neighboring gene uncharacterized LOC134481259

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-arginine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-arginine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-arginine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-histidine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-histidine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-lysine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-lysine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-lysine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-lysine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables L-ornithine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-ornithine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-ornithine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-ornithine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables basic amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables basic amino acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in L-amino acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-arginine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-arginine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-arginine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-histidine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-histidine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-lysine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-ornithine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-ornithine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-ornithine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-ornithine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in amino acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in basic amino acid transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in lysine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lysine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ornithine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    high affinity cationic amino acid transporter 1
    Names
    Solute carrier family 7 member A1 (amino acid transporter cationic 1)
    cationic amino acid transporter, y+ system
    cationinc amino acid transporter 1
    ecotropic retroviral leukemia receptor
    ecotropic retrovirus receptor
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
    system Y+ basic amino acid transporter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399982.2NP_001386911.1  high affinity cationic amino acid transporter 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      P70608, Q8VIA9
      Related
      ENSRNOP00000072647.1, ENSRNOT00000082850.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      11664488..11740030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271087.1XP_063127157.1  high affinity cationic amino acid transporter 1 isoform X1

      UniProtKB/TrEMBL
      P70608, Q8VIA9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_013111.3: Suppressed sequence

      Description
      NM_013111.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.