U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pon1 paraoxonase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84024, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pon1provided by RGD
    Official Full Name
    paraoxonase 1provided by RGD
    Primary source
    RGD:620062
    See related
    EnsemblRapid:ENSRNOG00000008902 AllianceGenome:RGD:620062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables aryldialkylphosphatase activity. Involved in several processes, including response to fatty acid; response to fluoride; and response to lipopolysaccharide. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 6153.2) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pon1 in Genome Data Viewer
    Location:
    4q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (34261312..34292327, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (33294737..33325759, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (30249749..30276297, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene cytoskeleton-associated protein 2, pseudogene 1 Neighboring gene protein phosphatase 1, regulatory subunit 9A Neighboring gene paraoxonase 3 Neighboring gene paraoxonase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acyl-L-homoserine-lactone lactonohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyl-L-homoserine-lactone lactonohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aryldialkylphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aryldialkylphosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aryldialkylphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables aryldialkylphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aryldialkylphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables arylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arylesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables arylesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables arylesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in carboxylic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carboxylic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lactone catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactone catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in negative regulation of plasma lipoprotein oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organophosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organophosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol efflux IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fluoride IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to toxic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spherical high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spherical high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serum paraoxonase/arylesterase 1
    Names
    A-esterase 1
    PON 1
    aromatic esterase 1
    serum aryldialkylphosphatase 1
    NP_114466.1
    XP_038964390.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032077.1NP_114466.1  serum paraoxonase/arylesterase 1

      See identical proteins and their annotated locations for NP_114466.1

      Status: VALIDATED

      Source sequence(s)
      CO562983, CO570909, U94856
      UniProtKB/Swiss-Prot
      O08682, P55159, Q5BJN6
      UniProtKB/TrEMBL
      A6IDT0
      Related
      ENSRNOP00000106355.1, ENSRNOT00000122056.1
      Conserved Domains (1) summary
      pfam01731
      Location:168253
      Arylesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      34261312..34292327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108462.2XP_038964390.1  serum paraoxonase/arylesterase 1 isoform X1

      Conserved Domains (1) summary
      pfam01731
      Location:81166
      Arylesterase