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    Cd74 CD74 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25599, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cd74provided by RGD
    Official Full Name
    CD74 moleculeprovided by RGD
    Primary source
    RGD:2313
    See related
    EnsemblRapid:ENSRNOG00000018735 AllianceGenome:RGD:2313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    INVG34
    Summary
    Predicted to enable several functions, including amyloid-beta binding activity; macrophage migration inhibitory factor binding activity; and signaling receptor binding activity. Predicted to contribute to cytokine binding activity. Involved in positive regulation of MAPK cascade. Predicted to be located in several cellular components, including external side of plasma membrane; lysosome; and multivesicular body. Predicted to be part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Predicted to be active in cell surface and cytoplasm. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 7990.4), Thymus (RPKM 4614.0) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cd74 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (56527071..56536406)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (54256757..54266003)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (56071420..56080851)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene N-deacetylase and N-sulfotransferase 1 Neighboring gene ribosomal protein S14 Neighboring gene treacle ribosome biogenesis factor 1 Neighboring gene uncharacterized LOC102550733

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CD4 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables CD4 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class II protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MHC class II protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class II protein binding, via antigen binding groove IEA
    Inferred from Electronic Annotation
    more info
     
    enables MHC class II protein binding, via antigen binding groove ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class II protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to cytokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to cytokine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables macrophage migration inhibitory factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables macrophage migration inhibitory factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables macrophage migration inhibitory factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nitric-oxide synthase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antigen processing and presentation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within defense response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within immunoglobulin mediated immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macrophage migration inhibitory factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macrophage migration inhibitory factor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mature B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mature B cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of peptide secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of peptide secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of chemokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendritic cell antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic cell antigen processing and presentation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of macrophage cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of macrophage migration inhibitory factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage migration inhibitory factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of monocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type 2 immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of type 2 immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein trimerization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction involved in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MHC class II protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NOS2-CD74 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NOS2-CD74 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of macrophage migration inhibitory factor receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of macrophage migration inhibitory factor receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of macrophage migration inhibitory factor receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vacuole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    H-2 class II histocompatibility antigen gamma chain
    Names
    Cd74 molecule, major histocompatibility complex, class II invariant chain
    MHC class II-associated invariant chain
    ia antigen-associated invariant chain
    ii

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013069.2NP_037201.1  H-2 class II histocompatibility antigen gamma chain

      See identical proteins and their annotated locations for NP_037201.1

      Status: VALIDATED

      Source sequence(s)
      BC059152, CB611598, CB696567
      UniProtKB/TrEMBL
      A6IXD0, Q6GT70
      Related
      ENSRNOP00000025354.6, ENSRNOT00000025354.9
      Conserved Domains (2) summary
      pfam08831
      Location:120185
      MHCassoc_trimer; Class II MHC-associated invariant chain trimerization domain
      pfam09307
      Location:1112
      MHC2-interact; CLIP, MHC2 interacting

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      56527071..56536406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254761.5XP_006254823.1  H-2 class II histocompatibility antigen gamma chain isoform X1

      See identical proteins and their annotated locations for XP_006254823.1

      UniProtKB/Swiss-Prot
      P10247
      UniProtKB/TrEMBL
      A6IXD2
      Related
      ENSRNOP00000106590.1, ENSRNOT00000169076.1
      Conserved Domains (3) summary
      cd00191
      Location:196255
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam08831
      Location:120185
      MHCassoc_trimer; Class II MHC-associated invariant chain trimerisation domain
      pfam09307
      Location:1113
      MHC2-interact; CLIP, MHC2 interacting