U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fcer2 Fc epsilon receptor II [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171075, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fcer2provided by RGD
    Official Full Name
    Fc epsilon receptor IIprovided by RGD
    Primary source
    RGD:619997
    See related
    EnsemblRapid:ENSRNOG00000001005 AllianceGenome:RGD:619997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CD23; Fcer2a
    Summary
    Predicted to enable several functions, including IgE binding activity; low-affinity IgE receptor activity; and protease binding activity. Predicted to be involved in several processes, including Fc receptor-mediated immune complex endocytosis; positive regulation of nitric-oxide synthase activity; and positive regulation of nitric-oxide synthase biosynthetic process. Predicted to act upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human FCER2 (Fc epsilon receptor II). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 57.4), Heart (RPKM 28.3) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fcer2 in Genome Data Viewer
    Location:
    12p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (6540697..6552364, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (1742809..1754476, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2233772..2245324, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene foxo1-corepressor-like Neighboring gene trafficking protein particle complex subunit 5 Neighboring gene C-type lectin domain family 4, member G Neighboring gene CD209a molecule

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93219

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables IgE binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables low-affinity IgE receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    low affinity immunoglobulin epsilon Fc receptor
    Names
    Fc fragment of IgE receptor II
    Fc fragment of IgE, low affinity II, receptor for (CD23)
    Fc receptor alpha multiple ligand receptor
    Fc receptor, IgE, low affinity II, alpha polypeptide
    Fcalpha RII
    Fcalpha muR

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033924.1NP_001029096.1  low affinity immunoglobulin epsilon Fc receptor isoform a

      See identical proteins and their annotated locations for NP_001029096.1

      Status: VALIDATED

      Source sequence(s)
      BC078749
      UniProtKB/TrEMBL
      F7EKM2, Q6AZ45, Q8R4T3
      Related
      ENSRNOP00000001332.4, ENSRNOT00000001332.8
      Conserved Domains (2) summary
      cd03590
      Location:186306
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:60170
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_133550.2NP_598234.2  low affinity immunoglobulin epsilon Fc receptor isoform b

      See identical proteins and their annotated locations for NP_598234.2

      Status: VALIDATED

      Source sequence(s)
      BC078749, X73579
      UniProtKB/TrEMBL
      A6KQ36, Q63097
      Related
      ENSRNOP00000085732.2, ENSRNOT00000102279.2
      Conserved Domains (2) summary
      cd03590
      Location:165285
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:67149
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      6540697..6552364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)