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    Azgp1 alpha-2-glycoprotein 1, zinc-binding [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25294, updated on 27-Nov-2024

    Summary

    Official Symbol
    Azgp1provided by RGD
    Official Full Name
    alpha-2-glycoprotein 1, zinc-bindingprovided by RGD
    Primary source
    RGD:2187
    See related
    EnsemblRapid:ENSRNOG00000001333 AllianceGenome:RGD:2187
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ZA2GA; Zna2gp
    Summary
    Involved in cellular response to insulin stimulus and cellular response to magnesium ion. Predicted to be active in external side of plasma membrane and extracellular space. Biomarker of chronic kidney disease; epilepsy; liver disease (multiple); obesity; and rheumatoid arthritis. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human AZGP1 (alpha-2-glycoprotein 1, zinc-binding). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 3096.2) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Azgp1 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (22044685..22051248)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (16930990..16939333)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19196565..19203094)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 like 15 Neighboring gene gap junction protein, gamma 3 Neighboring gene coiled-coil domain containing 90B, pseudogene 1 Neighboring gene ribosomal protein L34, pseudogene 3 Neighboring gene zinc finger with KRAB and SCAN domains 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Clone Names

    • MGC124966

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc-alpha-2-glycoprotein
    Names
    Zn - alpha2 - glycoprotein
    alpha-2 - glycoprotein 1, zinc
    alpha-2-glycoprotein 1, zinc
    zn-alpha-2-GP
    zn-alpha-2-glycoprotein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012826.2NP_036958.2  zinc-alpha-2-glycoprotein precursor

      See identical proteins and their annotated locations for NP_036958.2

      Status: PROVISIONAL

      Source sequence(s)
      BC105822
      UniProtKB/Swiss-Prot
      Q63523, Q63678
      UniProtKB/TrEMBL
      A0A8I6A9I2, A6KSS1, Q3B8R6
      Related
      ENSRNOP00000001801.5, ENSRNOT00000001801.8
      Conserved Domains (2) summary
      cl08246
      Location:21196
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:200291
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      22044685..22051248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249003.5XP_006249065.1  zinc-alpha-2-glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      Q63523, Q63678
      Conserved Domains (2) summary
      cl08246
      Location:21242
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:246337
      Ig; Immunoglobulin domain
    2. XM_006249004.5XP_006249066.1  zinc-alpha-2-glycoprotein isoform X2

      UniProtKB/Swiss-Prot
      Q63523, Q63678
      UniProtKB/TrEMBL
      F7F110
      Related
      ENSRNOP00000088478.2, ENSRNOT00000102149.2
      Conserved Domains (2) summary
      cl08246
      Location:21237
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cl11960
      Location:241332
      Ig; Immunoglobulin domain