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    Afm afamin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282708, updated on 27-Nov-2024

    Summary

    Official Symbol
    Afmprovided by RGD
    Official Full Name
    afaminprovided by RGD
    Primary source
    RGD:628614
    See related
    EnsemblRapid:ENSRNOG00000002878 AllianceGenome:RGD:628614
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable vitamin E binding activity. Predicted to be involved in protein stabilization; protein transport within extracellular region; and vitamin transport. Located in extracellular space. Orthologous to human AFM (afamin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 2940.0) See more
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    Genomic context

    See Afm in Genome Data Viewer
    Location:
    14p22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (17815194..17848042, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (17531022..17563868, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (19078678..19132212, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene Ras association domain family member 6 Neighboring gene uncharacterized LOC120096582 Neighboring gene albumin superfamily member 1 Neighboring gene uncharacterized LOC134481727 Neighboring gene uncharacterized LOC134481728 Neighboring gene alpha-fetoprotein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables vitamin E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables vitamin E binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables vitamin E binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables vitamin E binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport within extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport within extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport within extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vitamin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vitamin transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vitamin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    afamin
    Names
    alpha-Alb
    alpha-albumin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172320.2NP_758823.2  afamin precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6KKF6, G3V9R9
      Related
      ENSRNOP00000057275.2, ENSRNOT00000060535.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      17815194..17848042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091644.2XP_038947572.1  afamin isoform X1

      Conserved Domains (1) summary
      cd00015
      Location:222405
      ALBUMIN; Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; ...