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    Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25279, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cyp24a1provided by RGD
    Official Full Name
    cytochrome P450, family 24, subfamily a, polypeptide 1provided by RGD
    Primary source
    RGD:2462
    See related
    EnsemblRapid:ENSRNOG00000013062 AllianceGenome:RGD:2462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp24; VITD12; 24-OHase; 24R-Ohase; P450-CC24
    Summary
    Enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; and vitamin D 25-hydroxylase activity. Involved in cellular response to vitamin D and vitamin D catabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in colorectal adenoma; gastrointestinal system cancer (multiple); hypercalcemia; lung cancer (multiple); and ulcerative colitis. Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 83.5) See more
    Orthologs
    NEW
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    Genomic context

    See Cyp24a1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (179694647..179709083, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (159275947..159290383, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (168097484..168111920, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101805 Neighboring gene brain enriched myelin associated protein 1 Neighboring gene uncharacterized LOC134486493 Neighboring gene uncharacterized LOC134486494 Neighboring gene uncharacterized LOC134486492 Neighboring gene prefoldin subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables 25-hydroxycholecalciferol-23-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 25-hydroxycholecalciferol-24-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 25-hydroxycholecalciferol-24-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 25-hydroxycholecalciferol-24-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 25-hydroxycholecalciferol-24-hydroxylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    enables vitamin D 24-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vitamin D 25-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables vitamin D 25-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vitamin D 25-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to vitamin D IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to vitamin D ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vitamin D catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vitamin D catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vitamin D catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin D catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vitamin D metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within vitamin D metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin D metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
    Names
    25-hydroxyvitamin D3 24-hydroxylase
    25-hydroxyvitaminD324-hydroxylase
    Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase)
    cytochrome P450 24A1
    cytochrome P450, subfamily 24
    cytochrome P450-CC24
    vitamin D(3) 24-hydroxylase
    NP_963966.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201635.3NP_963966.1  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_963966.1

      Status: VALIDATED

      Source sequence(s)
      BC100059
      UniProtKB/Swiss-Prot
      Q09128, Q498V4, Q63685
      UniProtKB/TrEMBL
      A0A8I6A8M6, A6JXS6
      Related
      ENSRNOP00000043298.2, ENSRNOT00000046011.4
      Conserved Domains (1) summary
      cd20645
      Location:90508
      CYP24A1; cytochrome P450 family 24, subfamily A, polypeptide 1, also called vitamin D(3) 24-hydroxylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      179694647..179709083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)