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    Ambn ameloblastin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25376, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ambnprovided by RGD
    Official Full Name
    ameloblastinprovided by RGD
    Primary source
    RGD:2101
    See related
    EnsemblRapid:ENSRNOG00000003718 AllianceGenome:RGD:2101
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable growth factor activity. Predicted to be involved in cell adhesion and regulation of cell population proliferation. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1F. Orthologous to human AMBN (ameloblastin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 12.7), Testes (RPKM 4.0) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ambn in Genome Data Viewer
    Location:
    14p22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (19885802..19898422, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (19601761..19614382, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (21239887..21252534, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene joining chain of multimeric IgA and IgM Neighboring gene enamelin Neighboring gene small nucleolar RNA SNORA76 Neighboring gene amelotin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of tooth enamel IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of tooth enamel TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012900.2NP_037032.1  ameloblastin precursor

      See identical proteins and their annotated locations for NP_037032.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q540J9, Q62840, Q63043
      UniProtKB/TrEMBL
      A6KKJ9
      Related
      ENSRNOP00000087626.1, ENSRNOT00000105630.2
      Conserved Domains (1) summary
      pfam05111
      Location:5422
      Amelin; Ameloblastin precursor (Amelin)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      19885802..19898422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)