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    Cht9 Chitinase 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cht9provided by FlyBase
    Official Full Name
    Chitinase 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0034582
    Locus tag
    Dmel_CG10531
    See related
    AllianceGenome:FB:FBgn0034582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10531; Cht; cht9; DmCht9; DmCHT9; Dmel\CG10531
    Summary
    Enables chitinase activity. Involved in several processes, including chitin catabolic process; chitin-based cuticle development; and ecdysis, chitin-based cuticle. Located in extracellular space. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cht9 in Genome Data Viewer
    Location:
    57B16-57B16; 2-92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21067992..21069286, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16955497..16956791, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Chitinase 8 Neighboring gene Chitinase 12 Neighboring gene antisense RNA:CR44703 Neighboring gene Chitinase 4 Neighboring gene antisense RNA:CR44704 Neighboring gene uncharacterized protein Neighboring gene Trehalase Neighboring gene Rabaptin-5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of recombinant chitinase-like proteins of Drosophila melanogaster and Tribolium castaneum. Zhu Q, et al. Insect Biochem Mol Biol, 2008 Apr. PMID 18342251
    2. Inhibition of fatty acid desaturation impairs cuticle differentiation in Drosophila melanogaster. Wang Y, et al. Arch Insect Biochem Physiol, 2019 Apr. PMID 30672604
    3. Computational identification of novel chitinase-like proteins in the Drosophila melanogaster genome. Zhu Q, et al. Bioinformatics, 2004 Jan 22. PMID 14734306
    4. Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family. Funkhouser JD, et al. BMC Evol Biol, 2007 Jun 26. PMID 17594485, Free PMC Article
    5. Tramtrack is genetically upstream of genes controlling tracheal tube size in Drosophila. Rotstein B, et al. PLoS One, 2011. PMID 22216153, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chitinase 9
    Names
    CG10531-PA
    Cht9-PA
    NP_611543.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21067992..21069286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137699.5 → NP_611543.3  chitinase 9 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611543.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YXW0, Q8SZW4, Q9W2M5
      Related
      FBpp0071471
      Conserved Domains (2) summary
      cd02872
      Location:23 → 366
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:23 → 346
      Glyco_18; Glyco_18 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YXW0 Q7YXW0
    Q9W2M5 Q9W2M5

    Gene LinkOut

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