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    dos daughter of sevenless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38321, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dosprovided by FlyBase
    Official Full Name
    daughter of sevenlessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016794
    Locus tag
    Dmel_CG1044
    See related
    AllianceGenome:FB:FBgn0016794
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    141511_at; CG1044; Dmel\CG1044; Dos; DOS; E(csw)3A; E(csw[CS])3A; EC3-4; Gab-1; Su(sev)3A; Su(sev[S11])3A
    Summary
    Enables SH2 domain binding activity. Involved in photoreceptor cell differentiation; regulation of Ras protein signal transduction; and torso signaling pathway. Located in cytoplasm and plasma membrane. Is expressed in eye disc morphogenetic furrow; eye disc posterior to the morphogenetic furrow; and eye-antennal disc. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to several human genes including GAB1 (GRB2 associated binding protein 1); GAB2 (GRB2 associated binding protein 2); and GAB3 (GRB2 associated binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dos in Genome Data Viewer
    Location:
    62E7-62E7; 3-3 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2589414..2595590)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2589414..2595590)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene misshapen Neighboring gene Ribosomal protein L8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen. Kiely E, et al. MicroPubl Biol, 2021. PMID 34316546, Free PMC Article
    2. Interactions of the N- and C-Terminal SH3 Domains of Drosophila Drk with the Proline-Rich Peptides from Sos and Dos. Sayeesh PM, et al. Int J Mol Sci, 2023 Sep 15. PMID 37762438, Free PMC Article
    3. Insight into the C-terminal SH3 domain mediated binding of Drosophila Drk to Sos and Dos. Sayeesh PM, et al. Biochem Biophys Res Commun, 2022 Oct 15. PMID 35952612
    4. Protein tyrosine phosphatases in signal transduction. Neel BG, et al. Curr Opin Cell Biol, 1997 Apr. PMID 9069265
    5. Immune signalling: SHP-2 docks at multiple ports. Huyer G, et al. Curr Biol, 1999 Feb 25. PMID 10074424

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interactions of the N- and C-Terminal SH3 Domains of Drosophila Drk with the Proline-Rich Peptides from Sos and Dos.
      Title: Interactions of the N- and C-Terminal SH3 Domains of Drosophila Drk with the Proline-Rich Peptides from Sos and Dos.
    2. identifies DRK/DOS/SOS as the upstream Rac GEF complex required for glial responses to axonal injury, and demonstrates a critical requirement for multiple GEFs in efficient glial activation after injury and internalization/degradation of axonal debris
      Title: DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris.
    3. SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases.
      Title: SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases.
    4. Signalling from the pTyr (YB) Neu (ErbB-2) autophosphorylation site was affected by a haplosufficiency in drk (Grb-2), and in genes thought to function downstream of Grb-2: dab, sos, csw (Shp-2), and dos (Gab-1).
      Title: Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in R7 cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in R7 cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anterior/posterior axis specification, embryo TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in photoreceptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sevenless signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in torso signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in torso signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    daughter of sevenless
    Names
    CG1044-PA
    CG1044-PB
    dos-PA
    dos-PB
    enhancer of corkscrew-CS
    suppressor of sevenless-S11

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2589414..2595590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167956.2 → NP_728757.1  daughter of sevenless, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728757.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VZZ9
      Related
      FBpp0072804
      Conserved Domains (2) summary
      pfam00169
      Location:2 → 33
      PH; PH domain
      cl17171
      Location:1 → 35
      PH-like; Pleckstrin homology-like domain

    2. NM_079166.3 → NP_523890.2  daughter of sevenless, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523890.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24452, Q9VZZ9, Q9W000
      UniProtKB/TrEMBL
      L7RZC6
      Related
      FBpp0072803
      Conserved Domains (2) summary
      cd13384
      Location:2 → 115
      PH_Gab2_2; Grb2-associated binding protein family pleckstrin homology (PH) domain
      pfam00169
      Location:6 → 113
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZZ9.1 Q9VZZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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