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    thr three rows [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37042, updated on 9-Dec-2024

    Summary

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    Official Symbol
    thrprovided by FlyBase
    Official Full Name
    three rowsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003701
    Locus tag
    Dmel_CG5785
    See related
    AllianceGenome:FB:FBgn0003701
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ana; anch; CG5785; Dmel\CG5785; frag1; Thr; THR
    Summary
    Involved in several processes, including digestive tract development; head involution; and mitotic sister chromatid separation. Located in cytoplasm. Is expressed in embryonic brain; larval ventral nerve cord; organism; presumptive embryonic/larval central nervous system; and presumptive embryonic/larval peripheral nervous system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See thr in Genome Data Viewer
    Location:
    54F3-54F4; 2-84 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17861273..17865963, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13748778..13753468, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene olf186-M Neighboring gene orai Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44417 Neighboring gene mapmodulin Neighboring gene uncharacterized protein Neighboring gene Eag-like K[+] channel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the Drosophila melanogaster gene three rows permit aspects of mitosis to continue in the absence of chromatid segregation. Philp AV, et al. J Cell Sci, 1993 Sep. PMID 8270646
    2. Mutations in the Drosophila Melanogaster gene three rows permit aspects of mitosis to continue in the absence of chromatid segregation. Philp AV, et al. J Cell Sci, 1994 May. PMID 7929620
    3. Separase: a conserved protease separating more than just sisters. Ross KE, et al. Trends Cell Biol, 2002 Jan. PMID 11853993
    4. Chromosome cohesion and separation: from men and molecules. Uhlmann F. Curr Biol, 2003 Feb 4. PMID 12573239
    5. Sister chromatid cohesion and recombination in meiosis. van Heemst D, et al. Chromosoma, 2000. PMID 10855491

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function.
      Title: Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in digestive tract mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head involution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    three rows
    Names
    CG5785-PB
    CG5785-PC
    anarchist
    fragmented gonads 1
    separase
    thr-PB
    thr-PC
    three row

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17861273..17865963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299623.1 → NP_001286552.1  three rows, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286552.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42286, Q8MQL8, Q94525, Q9V894
      UniProtKB/TrEMBL
      A0A0B4LFY0

    2. NM_166257.2 → NP_725731.2  three rows, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725731.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42286, Q8MQL8, Q94525, Q9V894
      UniProtKB/TrEMBL
      A0A0B4LFY0
      Related
      FBpp0086004
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFY0 A0A0B4LFY0
    P42286.2 P42286

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
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