U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    O-fut1 O-fucosyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36564, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    O-fut1provided by FlyBase
    Official Full Name
    O-fucosyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033901
    Locus tag
    Dmel_CG12366
    See related
    AllianceGenome:FB:FBgn0033901
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4R6; AAF58290.1; CG12366; Dmel\CG12366; l(2)SH2 2260; l(2)SH2260; ntc; nti; O-fut; o-fut1; O-FUT1; Ofut-1; OFUT-1; Ofut1; OFut1; OFUT1
    Summary
    Enables Notch binding activity and peptide-O-fucosyltransferase activity. Involved in cell fate commitment; positive regulation of Notch signaling pathway; and positive regulation of endocytosis. Located in endoplasmic reticulum. Is expressed in several structures, including adult head; central nervous system; embryonic/larval lymph gland; germline cell; and imaginal disc. Human ortholog(s) of this gene implicated in Dowling-Degos disease. Orthologous to human POFUT1 (protein O-fucosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See O-fut1 in Genome Data Viewer
    Location:
    50E1-50E1; 2-69 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14161430..14163054)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10048935..10050559)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene peanuts Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cysteinyl-tRNA synthetase, mitochondrial Neighboring gene eukaryotic translation initiation factor 3 subunit m Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. [Regulation of notch signaling by O-linked glycosylations]. Ayukawa T, et al. Tanpakushitsu Kakusan Koso, 2008 Sep. PMID 21089381
    2. Cell biology. Does Notch take the sweet road to success? Lowe JB. Science, 2005 Mar 11. PMID 15761143
    3. Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats. Luo Y, et al. J Biol Chem, 2006 Apr 7. PMID 16464857
    4. Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. Wang Y, et al. J Biol Chem, 2001 Oct 26. PMID 11524432
    5. A synthetic gene drive system for local, reversible modification and suppression of insect populations. Akbari OS, et al. Curr Biol, 2013 Apr 22. PMID 23541732, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glycosylation of Specific Notch EGF Repeats by O-Fut1 and Fringe Regulates Notch Signaling in Drosophila.
      Title: Glycosylation of Specific Notch EGF Repeats by O-Fut1 and Fringe Regulates Notch Signaling in Drosophila.
    2. It regulates notch signaling by glycosylation.(review)
      Title: [Regulation of notch signaling by O-linked glycosylations].
    3. For Notch signaling in Drosophila, the chaperone activity of OFUT1 is sufficient for the generation of functional Notch.
      Title: Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling.
    4. O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila.
      Title: The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila.
    5. Down-regulation of OFUT1 by RNA interference in Notch-secreting cells inhibits both Delta-Notch and Serrate-Notch binding, demonstrating a requirement for O-linked fucose for efficient binding of Notch to its ligands
      Title: Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe.
    6. OFUT1 has a distinct Notch chaperone activity; binds to Notch; required for the trafficking of wild-type Notch out of the endoplasmic reticulum; ability to facilitate folding of Notch
      Title: Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding.
    7. that OFUT1 is a core component of the Notch pathway, which is required for the activation of Notch by its ligands, and whose regulation may contribute to the pattern of Notch activation during development
      Title: Regulation of notch signaling by o-linked fucose.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Notch binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peptide-O-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-O-fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-O-fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Notch signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in O-glycan processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked fucosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    O-fucosyltransferase 1
    Names
    CG12366-PA
    CG12366-PB
    O-fucosyl transferase
    O-fucosyltransferase
    O-fut1-PA
    O-fut1-PB
    neurotic
    protein O-fucosyltransferase 1
    NP_001286406.1
    NP_610931.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14161430..14163054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299477.1 → NP_001286406.1  O-fucosyltransferase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286406.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5BIC9, Q86SA7, Q8MSR1, Q9V6X7
      UniProtKB/TrEMBL
      A8E6L6
      Conserved Domains (2) summary
      cd11302
      Location:28 → 388
      O-FucT-1; GDP-fucose protein O-fucosyltransferase 1
      pfam10250
      Location:38 → 381
      O-FucT; GDP-fucose protein O-fucosyltransferase

    2. NM_137087.3 → NP_610931.1  O-fucosyltransferase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610931.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5BIC9, Q86SA7, Q8MSR1, Q9V6X7
      UniProtKB/TrEMBL
      A8E6L6
      Related
      FBpp0086649
      Conserved Domains (2) summary
      cd11302
      Location:28 → 388
      O-FucT-1; GDP-fucose protein O-fucosyltransferase 1
      pfam10250
      Location:38 → 381
      O-FucT; GDP-fucose protein O-fucosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8E6L6 A8E6L6
    Q9V6X7.1 Q9V6X7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools