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    omd oocyte maintenance defects [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    omdprovided by FlyBase
    Official Full Name
    oocyte maintenance defectsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038168
    Locus tag
    Dmel_CG9591
    See related
    AllianceGenome:FB:FBgn0038168
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9591; Dmel\CG9591; intS5; IntS5; Omd
    Summary
    Enables DNA binding activity. Involved in several processes, including negative regulation of BMP signaling pathway; positive regulation of neuron differentiation; and snRNA 3'-end processing. Located in cytosol and nucleus. Orthologous to human INTS5 (integrator complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See omd in Genome Data Viewer
    Location:
    87F9-87F11; 3-54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13679440..13687210, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9505162..9512932, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TWIK-related acid-sensitive K[+] channel 6 Neighboring gene uncharacterized protein Neighboring gene Lkb1 kinase Neighboring gene falafel Neighboring gene uncharacterized protein Neighboring gene flyers-cup Neighboring gene neither inactivation nor afterpotential B Neighboring gene Adenosine deaminase-related growth factor D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of Drosophila eye development by the transcription factor Sine oculis. Jusiak B, et al. PLoS One, 2014. PMID 24586968, Free PMC Article
    2. The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells. Zhang Y, et al. Cell Rep, 2019 Apr 23. PMID 31018143
    3. Accurate gene-tree reconstruction by learning gene- and species-specific substitution rates across multiple complete genomes. Rasmussen MD, et al. Genome Res, 2007 Dec. PMID 17989260, Free PMC Article
    4. The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division. Bonaccorsi S, et al. Development, 2007 Jun. PMID 17507418
    5. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    oocyte maintenance defects
    Names
    CG9591-PA
    CG9591-PB
    CG9591-PC
    integrator 5
    omd-PA
    omd-PB
    omd-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13679440..13687210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275613.1 → NP_001262542.1  oocyte maintenance defects, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262542.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95R54, Q9VFS6
      Conserved Domains (2) summary
      pfam14837
      Location:4 → 221
      INTS5_N; Integrator complex subunit 5 N-terminus
      pfam14838
      Location:229 → 962
      INTS5_C; Integrator complex subunit 5 C-terminus

    2. NM_142046.2 → NP_650303.1  oocyte maintenance defects, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650303.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95R54, Q9VFS6
      Related
      FBpp0082313
      Conserved Domains (2) summary
      pfam14837
      Location:4 → 221
      INTS5_N; Integrator complex subunit 5 N-terminus
      pfam14838
      Location:229 → 962
      INTS5_C; Integrator complex subunit 5 C-terminus

    3. NM_001275614.1 → NP_001262543.1  oocyte maintenance defects, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95R54, Q9VFS6
      Conserved Domains (2) summary
      pfam14837
      Location:4 → 221
      INTS5_N; Integrator complex subunit 5 N-terminus
      pfam14838
      Location:229 → 962
      INTS5_C; Integrator complex subunit 5 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFS6.2 Q9VFS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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