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    IKKbeta I-kappaB kinase beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IKKbetaprovided by FlyBase
    Official Full Name
    I-kappaB kinase betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024222
    Locus tag
    Dmel_CG4201
    See related
    AllianceGenome:FB:FBgn0024222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-89Bd; CG4201; DIK; dIKK; dIKK-beta; dIKKbeta; dLak; DLAK; Dmel\CG4201; DmIKK; Dmikkb; DmIKKb; dmIKKbeta; Dmikkbeta; DmIkkbeta; DmIKKbeta; DmIKKBeta; Ik; IK; ikk; IKK; IKK-beta; Ikkb; IKKb; IKKB; Ikkbeta; IKKBeta; ird; ird-5; Ird-5; IRD-5; ird5; Ird5; IRD5; ird5/DmIkk[beta]; ird[5]; Lak; LRK
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including defense response to symbiont; positive regulation of canonical NF-kappaB signal transduction; and regulation of defense response. Located in cytoplasm. Is expressed in several structures, including adult Malpighian tubule; fat body/gonad primordium; germline cell; and gonad. Human ortholog(s) of this gene implicated in several diseases, including combined immunodeficiency (multiple); fetal encasement syndrome; liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex) and IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See IKKbeta in Genome Data Viewer
    Location:
    89B1-89B1; 3-58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16046347..16049421, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11872069..11875143, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pannier Neighboring gene Juvenile hormone binding protein 4 Neighboring gene long non-coding RNA:CR45212 Neighboring gene Juvenile hormone binding protein 5 Neighboring gene uncharacterized protein Neighboring gene mini spindles Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster. Bandarra D, et al. Biosci Rep, 2014 Jul 29. PMID 24993778, Free PMC Article
    2. Verloren negatively regulates the expression of IMD pathway dependent antimicrobial peptides in Drosophila. Prakash P, et al. Sci Rep, 2021 Jul 30. PMID 34330981, Free PMC Article
    3. Inhibition of kinase IKKβ suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6. Padash Barmchi M, et al. Sci Rep, 2021 Jan 13. PMID 33441820, Free PMC Article
    4. Stop press: genes that fight infections: what the drosophila genome says about animal immunity. Khush RS, et al. Trends Genet, 2000 Oct. PMID 11050334
    5. ARMS-NF-κB signaling regulates intracellular ROS to induce autophagy-associated cell death upon oxidative stress. Liao YH, et al. iScience, 2023 Feb 17. PMID 36798436, Free PMC Article

    See all (165) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of kinase IKKbeta suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6.
      Title: Inhibition of kinase IKKβ suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to IkappaB kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cGAS/STING signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antibacterial peptide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of antibacterial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of IkappaB kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    I-kappaB kinase beta
    Names
    CG4201-PB
    IKK-like protein
    IKKbeta-PB
    LPS-responsive kinase
    LPS-responsive-kinase
    cactus kinase
    immune response deficient 5
    immune response-deficient 5
    lipopolysaccharide activated kinase
    mmune response deficient 5
    NP_524751.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16046347..16049421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080012.4 → NP_524751.3  I-kappaB kinase beta [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524751.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GYV6, Q9NJI1, Q9U698, Q9U7F5, Q9VEZ5
      Conserved Domains (2) summary
      smart00220
      Location:7 → 245
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:13 → 316
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEZ5.2 Q9VEZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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