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    CG12608 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32463, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12608provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030630
    Locus tag
    Dmel_CG12608
    See related
    AllianceGenome:FB:FBgn0030630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12608
    Summary
    Predicted to enable protein kinase inhibitor activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Orthologous to human PAK1IP1 (PAK1 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12608 in Genome Data Viewer
    Location:
    13B7-13B7; 1-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15342857..15344625, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15236890..15238658, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44998 Neighboring gene Histone deacetylase 6 Neighboring gene uncharacterized protein Neighboring gene pre-mRNA processing factor 5 Neighboring gene abnormal chemosensory jump 6 Neighboring gene Protein phosphatase 1 at 13C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. Xia S, et al. PLoS Genet, 2021 Jul. PMID 34242211, Free PMC Article
    2. Recent strong positive selection on Drosophila melanogaster HDAC6, a gene encoding a stress surveillance factor, as revealed by population genomic analysis. Svetec N, et al. Mol Biol Evol, 2009 Jul. PMID 19349642
    3. Excess of amino acid substitutions relative to polymorphism between X-linked duplications in Drosophila melanogaster. Thornton K, et al. Mol Biol Evol, 2005 Feb. PMID 15483321
    4. dCas9-targeted locus-specific protein isolation method identifies histone gene regulators. Tsui C, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507191, Free PMC Article
    5. MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila. Daneshvar K, et al. Biol Open, 2013 Jan 15. PMID 23336071, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12608-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15342857..15344625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132791.4 → NP_573019.1  uncharacterized protein Dmel_CG12608 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573019.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5I7A2, C5I7Q4, C5I7R2, Q960Y1, Q9VXW3
      Related
      FBpp0073835
      Conserved Domains (3) summary
      COG2319
      Location:33 → 289
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:51 → 85
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:45 → 295
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXW3 Q9VXW3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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