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    CG30389 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37410, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG30389provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050389
    Locus tag
    Dmel_CG30389
    See related
    AllianceGenome:FB:FBgn0050389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT02070; CG10518; CG4126; Dmel\CG30389
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in chemotaxis and neuronal signal transduction. Predicted to be active in nuclear membrane and rough endoplasmic reticulum membrane. Orthologous to human MACO1 (macoilin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG30389 in Genome Data Viewer
    Location:
    57C4-57C6; 2-93 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21148265..21160545, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17035770..17048050, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene X box binding protein-1 Neighboring gene High mobility group protein 2 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Glycine-GCC 1-12 Neighboring gene transfer RNA:Tryptophan-CCA 2-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ribosomal Protein RpL22 Interacts In Vitro with 5'-UTR Sequences Found in Some Drosophila melanogaster Transposons. Minervini CF, et al. Genes (Basel), 2022 Feb 5. PMID 35205350, Free PMC Article
    2. Genome-wide RNAi screen identifies broadly-acting host factors that inhibit arbovirus infection. Yasunaga A, et al. PLoS Pathog, 2014 Feb. PMID 24550726, Free PMC Article
    3. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Candia N, et al. Hum Genet, 2023 Aug. PMID 37368047
    4. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
    5. A gain-of-function screen for genes that influence axon guidance identifies the NF-kappaB protein dorsal and reveals a requirement for the kinase Pelle in Drosophila photoreceptor axon targeting. Mindorff EN, et al. Genetics, 2007 Aug. PMID 17603113, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in rough endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rough endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30389-PA
    CG30389-PC
    CG30389-PD
    CG30389-PE
    CG30389-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21148265..21160545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274189.1 → NP_001261118.1  uncharacterized protein Dmel_CG30389, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261118.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E901
      Conserved Domains (3) summary
      pfam09726
      Location:2 → 836
      Macoilin; Transmembrane protein
      pfam10211
      Location:567 → 654
      Ax_dynein_light; Axonemal dynein light chain
      cl23720
      Location:639 → 746
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_137711.4 → NP_611555.2  uncharacterized protein Dmel_CG30389, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611555.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E901
      Related
      FBpp0071555
      Conserved Domains (3) summary
      pfam09726
      Location:2 → 836
      Macoilin; Transmembrane protein
      pfam10211
      Location:567 → 654
      Ax_dynein_light; Axonemal dynein light chain
      cl23720
      Location:639 → 746
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. NM_001274188.1 → NP_001261117.1  uncharacterized protein Dmel_CG30389, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFE6
      Conserved Domains (3) summary
      pfam09726
      Location:2 → 836
      Macoilin; Transmembrane protein
      pfam10211
      Location:567 → 654
      Ax_dynein_light; Axonemal dynein light chain
      cl23720
      Location:639 → 746
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. NM_001274187.1 → NP_001261116.1  uncharacterized protein Dmel_CG30389, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEW2
      Conserved Domains (3) summary
      pfam09726
      Location:2 → 893
      Macoilin; Transmembrane protein
      pfam10211
      Location:624 → 711
      Ax_dynein_light; Axonemal dynein light chain
      cl23720
      Location:696 → 803
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    5. NM_137712.4 → NP_611556.2  uncharacterized protein Dmel_CG30389, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611556.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E901
      Related
      FBpp0071556
      Conserved Domains (3) summary
      pfam09726
      Location:2 → 836
      Macoilin; Transmembrane protein
      pfam10211
      Location:567 → 654
      Ax_dynein_light; Axonemal dynein light chain
      cl23720
      Location:639 → 746
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEW2 A0A0B4KEW2
    A0A0B4KFE6 A0A0B4KFE6
    Q0E901 Q0E901
    Q961P6 Q961P6

    Gene LinkOut

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