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    GILT3 Gamma-interferon-inducible lysosomal thiol reductase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GILT3provided by FlyBase
    Official Full Name
    Gamma-interferon-inducible lysosomal thiol reductase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0039098
    Locus tag
    Dmel_CG13822
    See related
    AllianceGenome:FB:FBgn0039098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13822; Dmel\CG13822; GILT; GILT-3
    Summary
    Predicted to enable oxidoreductase activity, acting on a sulfur group of donors. Is expressed in several structures, including amnioserosa; head mesoderm; spermatozoon; visceral mesoderm derivative; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GILT3 in Genome Data Viewer
    Location:
    95A7-95A7; 3-80 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23677358..23678421)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19503080..19504143)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gamma-interferon-inducible lysosomal thiol reductase 2 Neighboring gene eukaryotic translation initiation factor 3 subunit d1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of gamma-interferon-inducible lysosomal thiol reductase (GILT) homologues in the fruit fly Drosophila melanogaster. Kongton K, et al. Dev Comp Immunol, 2014 Jun. PMID 24491521
    2. Identification of a micropeptide and multiple secondary cell genes that modulate Drosophila male reproductive success. Immarigeon C, et al. Proc Natl Acad Sci U S A, 2021 Apr 13. PMID 33876742, Free PMC Article
    3. Machine learning classification of cell-specific cardiac enhancers uncovers developmental subnetworks regulating progenitor cell division and cell fate specification. Ahmad SM, et al. Development, 2014 Feb. PMID 24496624, Free PMC Article
    4. Integrative analysis unveils new functions for the Drosophila Cutoff protein in noncoding RNA biogenesis and gene regulation. Pritykin Y, et al. RNA, 2017 Jul. PMID 28420675, Free PMC Article
    5. Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. Greene JC, et al. Hum Mol Genet, 2005 Mar 15. PMID 15689351

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gamma-interferon-inducible lysosomal thiol reductase (GILT)homologue, role in the innate immune response upon bacterial challenge
      Title: Identification of gamma-interferon-inducible lysosomal thiol reductase (GILT) homologues in the fruit fly Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Gamma-interferon-inducible lysosomal thiol reductase 3
    Names
    CG13822-PA
    GILT3-PA
    Gamma-interferon-inducible lysosomal thiol reductase
    NP_651165.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23677358..23678421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142908.3 → NP_651165.1  Gamma-interferon-inducible lysosomal thiol reductase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCK2
      Related
      FBpp0083826
      Conserved Domains (1) summary
      pfam03227
      Location:33 → 127
      GILT; Gamma interferon inducible lysosomal thiol reductase (GILT)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCK2.1 Q9VCK2

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