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    Svil Supervillin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Svilprovided by FlyBase
    Official Full Name
    Supervillinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266696
    Locus tag
    Dmel_CG45186
    See related
    AllianceGenome:FB:FBgn0266696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c62E-11; CG1141; CG12790; CG13797; CG13798; CG13799; CG13800; CG16763; CG16764; CG32306; CG33231; CG33232; CG42669; CG45186; Dmel\CG45186
    Old locus tag
    Dmel_CG13800; Dmel_CG32306; Dmel_CG33231; Dmel_CG33232; Dmel_CG42669
    Summary
    Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including adult head; anlage in statu nascendi; central brain anlage in statu nascendi; dorsal ectoderm; and dorsal ectoderm anlage. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Svil in Genome Data Viewer
    Location:
    62D7-62E4; 3-3 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2377655..2499226)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2377655..2499226)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitotic spindle organizing protein 1 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4d20 Neighboring gene long non-coding RNA:CR45425 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 62E early-late puff of Drosophila contains D-spinophilin, an ecdysone-inducible PDZ-domain protein dynamically expressed during metamorphosis. Keegan J, et al. Genet Res, 2001 Feb. PMID 11279828
    2. Mind bomb 2 promotes cell migration and epithelial structure by regulating adhesion complexes and the actin cytoskeleton. Trivedi S, et al. Dev Biol, 2022 Nov. PMID 36067835
    3. The genetic basis of variation in Drosophila melanogaster mating behavior. Yamamoto A, et al. iScience, 2024 May 17. PMID 38766354, Free PMC Article
    4. [LTR retrotransposons as a source of promoters in the Drosophila genome]. Makunin IV, et al. Genetika, 2010 Sep. PMID 21061618
    5. Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function. Muhammad K, et al. Nat Commun, 2015 Oct 16. PMID 26471740, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 2447560-2456657 mobile_element_type = transposon:roo{}911

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    supervillin
    Names
    CG45186-PA
    CG45186-PAA
    CG45186-PAB
    CG45186-PAC
    CG45186-PAD
    CG45186-PAE
    CG45186-PAF
    CG45186-PAG
    CG45186-PAH
    CG45186-PC
    CG45186-PE
    CG45186-PF
    CG45186-PG
    CG45186-PH
    CG45186-PJ
    CG45186-PK
    CG45186-PL
    CG45186-PM
    CG45186-PN
    CG45186-PO
    CG45186-PP
    CG45186-PQ
    CG45186-PR
    CG45186-PS
    CG45186-PT
    CG45186-PU
    CG45186-PV
    CG45186-PW
    CG45186-PX
    CG45186-PY
    CG45186-PZ
    Svil-PA
    Svil-PAA
    Svil-PAB
    Svil-PAC
    Svil-PAD
    Svil-PAE
    Svil-PAF
    Svil-PAG
    Svil-PAH
    Svil-PC
    Svil-PE
    Svil-PF
    Svil-PG
    Svil-PH
    Svil-PJ
    Svil-PK
    Svil-PL
    Svil-PM
    Svil-PN
    Svil-PO
    Svil-PP
    Svil-PQ
    Svil-PR
    Svil-PS
    Svil-PT
    Svil-PU
    Svil-PV
    Svil-PW
    Svil-PX
    Svil-PY
    Svil-PZ
    villin-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2377655..2499226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274398.2 → NP_001261327.1  supervillin, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261327.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQG5, Q7KV98

    2. NM_001299988.1 → NP_001286917.1  supervillin, isoform AC [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286917.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCG0
      Conserved Domains (1) summary
      PRK11281
      Location:751 → 910
      PRK11281; hypothetical protein; Provisional

    3. NM_001202097.2 → NP_001189026.1  supervillin, isoform AH [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRN1
      Conserved Domains (2) summary
      PRK11281
      Location:751 → 910
      PRK11281; hypothetical protein; Provisional
      pfam06160
      Location:1607 → 1788
      EzrA; Septation ring formation regulator, EzrA

    4. NM_001299990.1 → NP_001286919.1  supervillin, isoform AE [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286919.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAM4
      Conserved Domains (5) summary
      cd11280
      Location:3859 → 3965
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:4176 → 4279
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:3733 → 3825
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:4491 → 4526
      VHP; Villin headpiece domain
      cl15697
      Location:4069 → 4158
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    5. NM_001299987.1 → NP_001286916.1  supervillin, isoform AB [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286916.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JC02
      Conserved Domains (1) summary
      PRK11281
      Location:812 → 971
      PRK11281; hypothetical protein; Provisional

    6. NM_139462.4 → NP_647719.2  supervillin, isoform AF [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647719.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W018
      Conserved Domains (2) summary
      PRK11281
      Location:812 → 971
      PRK11281; hypothetical protein; Provisional
      pfam06160
      Location:1668 → 1849
      EzrA; Septation ring formation regulator, EzrA

    7. NM_001299989.1 → NP_001286918.1  supervillin, isoform AD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286918.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J8M7
      Conserved Domains (1) summary
      PRK11281
      Location:751 → 910
      PRK11281; hypothetical protein; Provisional

    8. NM_001202098.2 → NP_001189027.1  supervillin, isoform AG [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189027.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRN1
      Conserved Domains (2) summary
      PRK11281
      Location:751 → 910
      PRK11281; hypothetical protein; Provisional
      pfam06160
      Location:1607 → 1788
      EzrA; Septation ring formation regulator, EzrA

    9. NM_001202101.1 → NP_001189030.1  supervillin, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQG5, Q7KV98

    10. NM_001202100.2 → NP_001189029.1  supervillin, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189029.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRP8

    11. NM_001169859.2 → NP_001163330.1  supervillin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163330.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIC0

    12. NM_206242.3 → NP_995964.2  supervillin, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995964.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQG5, Q7KV98

    13. NM_001169858.2 → NP_001163329.1  supervillin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163329.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIB9, Q6NNW7

    14. NM_001259639.1 → NP_001246568.1  supervillin, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246568.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFH6

    15. NM_001259637.1 → NP_001246566.1  supervillin, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246566.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQG5, Q7KV98

    16. NM_001259638.1 → NP_001246567.1  supervillin, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246567.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIB9, Q6NNW7

    17. NM_001274399.1 → NP_001261328.1  supervillin, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDU5, Q6NNW7

    18. NM_001299986.1 → NP_001286915.1  supervillin, isoform W [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286915.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JG79
      Conserved Domains (5) summary
      cd11280
      Location:2373 → 2479
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:2690 → 2793
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:2247 → 2339
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:3006 → 3040
      VHP; Villin headpiece domain
      cl15697
      Location:2583 → 2672
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    19. NM_001202102.2 → NP_001189031.1  supervillin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189031.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRN5

    20. NM_001202103.2 → NP_001189032.1  supervillin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189032.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRZ4

    21. NM_139464.4 → NP_647721.3  supervillin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647721.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQG5, Q9W016

    22. NM_001299985.1 → NP_001286914.1  supervillin, isoform V [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286914.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQG5, X2JAL9

    23. NM_001259636.1 → NP_001246565.1  supervillin, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLV0, M9NEY0

    24. NM_001202104.2 → NP_001189033.2  supervillin, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189033.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRU6, Q960Y7

    25. NM_206246.3 → NP_995968.2  supervillin, isoform X [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995968.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHM3, Q7KV92
      Conserved Domains (5) summary
      cd11280
      Location:847 → 953
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1164 → 1267
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:721 → 813
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:1480 → 1514
      VHP; Villin headpiece domain
      cl15697
      Location:1057 → 1146
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    26. NM_001202105.2 → NP_001189034.1  supervillin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRQ1

    27. NM_167948.1 → NP_728744.1  supervillin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W013
      Related
      FBpp0311321, FBtr0345096

    28. NM_167949.1 → NP_728745.1  supervillin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRF0
      Related
      FBpp0311320, FBtr0345095

    29. NM_001031933.3 → NP_001027104.1  supervillin, isoform Y [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027104.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHM3, Q0E8J1
      Conserved Domains (5) summary
      cd11280
      Location:489 → 595
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:806 → 909
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:363 → 455
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:1122 → 1156
      VHP; Villin headpiece domain
      cl15697
      Location:699 → 788
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    30. NM_206244.3 → NP_995966.1  supervillin, isoform Z [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995966.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHM3, Q0E8J1
      Conserved Domains (5) summary
      cd11280
      Location:489 → 595
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:806 → 909
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:363 → 455
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:1122 → 1156
      VHP; Villin headpiece domain
      cl15697
      Location:699 → 788
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    31. NM_001274400.1 → NP_001261329.1  supervillin, isoform AA [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261329.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHM3, M9PEC5
      Conserved Domains (5) summary
      cd11280
      Location:444 → 550
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:761 → 864
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:318 → 410
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:1077 → 1111
      VHP; Villin headpiece domain
      cl15697
      Location:654 → 743
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIB9 E1JIB9
    E1JIC0 E1JIC0
    M9MRN1 M9MRN1
    M9MRN5 M9MRN5
    M9MRP8 M9MRP8
    M9MRQ1 M9MRQ1
    M9MRU6 M9MRU6
    M9MRZ4 M9MRZ4
    M9NEY0 M9NEY0
    M9NFH6 M9NFH6
    M9PDU5 M9PDU5
    M9PEC5 M9PEC5
    Q0E8J1 Q0E8J1
    Q7KV92 Q7KV92
    Q7KV98 Q7KV98
    Q8IRF0 Q8IRF0
    Q95TG5 Q95TG5
    Q960Y7 Q960Y7
    Q9W013 Q9W013
    Q9W016 Q9W016
    Q9W018 Q9W018
    X2J8M7 X2J8M7
    X2JAL9 X2JAL9
    X2JAM4 X2JAM4
    X2JC02 X2JC02
    X2JCG0 X2JCG0
    X2JG79 X2JG79

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