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    CG6431 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6431provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032289
    Locus tag
    Dmel_CG6431
    See related
    AllianceGenome:FB:FBgn0032289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    chr2L_10724193_10724543.0; Dmel\CG6431
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6431 in Genome Data Viewer
    Location:
    32A5-32A5; 2-43 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10724203..10728740)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10724203..10728740)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Lipase 2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44407 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ER membrane protein complex subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
    2. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
    3. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    4. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6431-PB
    CG6431-PC
    NP_001188790.1
    NP_609442.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10724203..10728740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201861.2 → NP_001188790.1  uncharacterized protein Dmel_CG6431, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRT1
      Conserved Domains (1) summary
      cl21494
      Location:63 → 293
      Abhydrolase; alpha/beta hydrolases

    2. NM_135598.4 → NP_609442.2  uncharacterized protein Dmel_CG6431, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609442.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKR3
      Conserved Domains (1) summary
      cl21494
      Location:59 → 288
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRT1 M9MRT1
    Q9VKR3 Q9VKR3

    Gene LinkOut

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