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    Cys Cystatin-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41767, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cysprovided by FlyBase
    Official Full Name
    Cystatin-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004629
    Locus tag
    Dmel_CG8050
    See related
    AllianceGenome:FB:FBgn0004629
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-2.34; BcDNA:RH72992; CG8050; clone 2.34; cys; Dmel\CG8050
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including anterior endoderm anlage; dorsal ectoderm; dorsal epidermis primordium; embryonic dorsal epidermis; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cys in Genome Data Viewer
    Location:
    88C6-88C6; 3-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14569103..14569644, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10394825..10395366, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44095 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis, and chromosomal localization of a gene encoding a cystatin-like protein from Drosophila melanogaster. Delbridge ML, et al. FEBS Lett, 1990 Nov 12. PMID 1701398
    2. Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila. Kinser RD, et al. Neurobiol Dis, 2012 Jun. PMID 22426392
    3. Friends and relations of the cystatin superfamily--new members and their evolution. Brown WM, et al. Protein Sci, 1997 Jan. PMID 9007972, Free PMC Article
    4. Divergent allocation of sperm and the seminal proteome along a competition gradient in Drosophila melanogaster. Hopkins BR, et al. Proc Natl Acad Sci U S A, 2019 Sep 3. PMID 31431535, Free PMC Article
    5. Protein interactions on telomeric retrotransposons in Drosophila. Takács S, et al. Int J Biol Sci, 2012. PMID 22949888, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 

    General protein information

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    Preferred Names
    Cystatin-like
    Names
    CG8050-PA
    Cys-PA
    cystatin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14569103..14569644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057508.4 → NP_476856.1  Cystatin-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476856.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23779, Q8SZN3, Q9VFI2
      Related
      FBpp0082439
      Conserved Domains (1) summary
      smart00043
      Location:26 → 115
      CY; Cystatin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23779.2 P23779

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