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    PpV Protein phosphatase V [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PpVprovided by FlyBase
    Official Full Name
    Protein phosphatase Vprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003139
    Locus tag
    Dmel_CG12217
    See related
    AllianceGenome:FB:FBgn0003139
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12217; Dmel\CG12217; DmPpV-6A; dPP6; PP6; PPPV6A; ppv; Ppv; PPV; PPV 6A; PpV[[C]]
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in G1/S transition of mitotic cell cycle and negative regulation of JNK cascade. Located in cytoplasm. Is expressed in organism. Orthologous to human PPP6C (protein phosphatase 6 catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PpV in Genome Data Viewer
    Location:
    5F4-5F4; 1-16 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6371065..6372915, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6265098..6266948, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene swallow Neighboring gene long non-coding RNA:CR44816 Neighboring gene Mitochondrial assembly regulatory factor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila protein phosphatase V functionally complements a SIT4 mutant in Saccharomyces cerevisiae and its amino-terminal region can confer this complementation to a heterologous phosphatase catalytic domain. Mann DJ, et al. EMBO J, 1993 Dec. PMID 8223492, Free PMC Article
    2. Fluorescence fluctuation analysis reveals PpV dependent Cdc25 protein dynamics in living embryos. Liu B, et al. PLoS Genet, 2020 Apr. PMID 32251417, Free PMC Article
    3. Multiple Functions of the Essential Gene PpV in Drosophila Early Development. Liu B, et al. G3 (Bethesda), 2019 Nov 5. PMID 31484673, Free PMC Article
    4. Drosophila protein phosphatase V regulates lipid homeostasis via the AMPK pathway. Yin D, et al. J Mol Cell Biol, 2014 Feb. PMID 24334257
    5. Protein serine/threonine phosphatases; an expanding family. Cohen PT, et al. FEBS Lett, 1990 Aug 1. PMID 2166691

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Competition between two phosphatases fine-tunes Hedgehog signaling.
      Title: Competition between two phosphatases fine-tunes Hedgehog signaling.
    2. PpV controls directly or indirectly the phosphorylation of Twine at multiple serine and threonine residues. PpV tightly controls Twine dynamics in drosophila embryo.
      Title: Fluorescence fluctuation analysis reveals PpV dependent Cdc25 protein dynamics in living embryos.
    3. We identified a PpV function specifically in blastoderm cell cycle but not in cell proliferation in the follicle epithelium or larval wing imaginal discs. Embryos from PpV germline clones frequently undergo an extra nuclear division cycle. By epistasis analysis, we found that PpV functions in parallel with tribbles, but independently of auroraA for the remodeling of the nuclear cycles
      Title: Multiple Functions of the Essential Gene PpV in Drosophila Early Development.
    4. Disrupting the JNK signal transduction was adequate to suppress the ppv effects for wing development.
      Title: PpV, acting via the JNK pathway, represses apoptosis during normal development of Drosophila wing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase V
    Names
    CG12217-PA
    CG12217-PB
    CG12217-PC
    CG12217-PD
    PpV-PA
    PpV-PB
    PpV-PC
    PpV-PD
    NP_001259272.1
    NP_001259273.1
    NP_001259274.1
    NP_511061.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6371065..6372915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272344.1 → NP_001259273.1  protein phosphatase V, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259273.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27884, Q5BIJ4, Q8MRZ7, Q9W3Z8
      UniProtKB/TrEMBL
      M9PGI3
      Conserved Domains (2) summary
      PTZ00239
      Location:3 → 303
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
      cd07415
      Location:3 → 287
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    2. NM_001272345.1 → NP_001259274.1  protein phosphatase V, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27884, Q5BIJ4, Q8MRZ7, Q9W3Z8
      UniProtKB/TrEMBL
      M9PGI3
      Conserved Domains (2) summary
      PTZ00239
      Location:3 → 303
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
      cd07415
      Location:3 → 287
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    3. NM_001272343.1 → NP_001259272.1  protein phosphatase V, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259272.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27884, Q5BIJ4, Q8MRZ7, Q9W3Z8
      UniProtKB/TrEMBL
      M9PGI3
      Conserved Domains (2) summary
      PTZ00239
      Location:3 → 303
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
      cd07415
      Location:3 → 287
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    4. NM_078506.3 → NP_511061.1  protein phosphatase V, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511061.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27884, Q5BIJ4, Q8MRZ7, Q9W3Z8
      UniProtKB/TrEMBL
      M9PGI3
      Related
      FBpp0070883
      Conserved Domains (2) summary
      PTZ00239
      Location:3 → 303
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
      cd07415
      Location:3 → 287
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGI3 M9PGI3
    Q27884.1 Q27884

    Gene LinkOut

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