U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tld tolloid [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42945, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tldprovided by FlyBase
    Official Full Name
    tolloidprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003719
    Locus tag
    Dmel_CG6868
    See related
    AllianceGenome:FB:FBgn0003719
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6868; CT21278; Dmel\CG6868; dTld; Tld; TLD; Tolloid
    Summary
    Enables collagen binding activity and metalloendopeptidase activity. Involved in several processes, including R8 cell fate specification; amnioserosa formation; and positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in extracellular space. Is expressed in several structures, including anlage in statu nascendi; embryonic gnathal segment; epithelium; head epidermis primordium; and imaginal disc. Human ortholog(s) of this gene implicated in atrial heart septal defect 6; congenital heart disease; and coronary artery disease. Orthologous to human TLL1 (tolloid like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tld in Genome Data Viewer
    Location:
    96A19-96A19; 3-85 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24749731..24753510)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20575453..20579232)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II, I and III subunit L Neighboring gene tolkin Neighboring gene abnormal spindle Neighboring gene Allatostatin A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genome evolution and the evolution of exon-shuffling--a review. Patthy L. Gene, 1999 Sep 30. PMID 10570989
    2. Spatial and temporal expression pattern during sea urchin embryogenesis of a gene coding for a protease homologous to the human protein BMP-1 and to the product of the Drosophila dorsal-ventral patterning gene tolloid. Lepage T, et al. Development, 1992 Jan. PMID 1339338
    3. Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity. Lee HX, et al. Genes Dev, 2009 Nov 1. PMID 19884260, Free PMC Article
    4. Functional and structural insights into astacin metallopeptidases. Gomis-Rüth FX, et al. Biol Chem, 2012 Oct. PMID 23092796
    5. A molecular snapshot of the metazoan 'Eve'. Shenk MA, et al. Trends Biochem Sci, 1993 Dec. PMID 7906442

    See all (208) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These studies highlight how the bipartite function of Tolloid CUB domains, in substrate and extracellular matrix interactions, fine-tune protease activity to a particular developmental context.
      Title: Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation.
    2. BMP4 inhibits Tolloid enzyme activity noncompetitively
      Title: Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity.
    3. Robustness of the BMP morphogen gradient in Drosophila embryonic patterning
      Title: Robustness of the BMP morphogen gradient in Drosophila embryonic patterning.
    4. The effects of site-directed mutagenesis of tolloid protein on its' ability to cleave Sog protein are reported.
      Title: A complete domain structure of Drosophila tolloid is required for cleavage of short gastrulation.
    5. Data suggest that decapentaplegic (Dpp)concentration dependence, together with movement of Dpp by Sog and Tsg proteins, can explain how Tld activity is confined to the dorsal-most region of the embryo.
      Title: Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in R8 cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amnioserosa formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maternal specification of dorsal/ventral axis, oocyte, soma encoded IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of activin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    tolloid
    Names
    CG6868-PA
    tld-PA
    NP_524487.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24749731..24753510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079763.4 → NP_524487.2  tolloid [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524487.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25723, Q9VC46
      Related
      FBpp0084070
      Conserved Domains (5) summary
      smart00042
      Location:388 → 474
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      cd04281
      Location:137 → 338
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:478 → 586
      CUB; CUB domain
      pfam01400
      Location:144 → 339
      Astacin; Astacin (Peptidase family M12A)
      pfam14670
      Location:757 → 792
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25723.2 P25723
    Q7YU36 Q7YU36

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous