mGluR metabotropic Glutamate Receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mGluRprovided by FlyBase
Official Full Name: metabotropic Glutamate Receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0019985
Locus tag: Dmel_CG11144
See related: AllianceGenome:FB:FBgn0019985
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CAA67993.1_Dr; CG11144; Dmel\CG11144; DmGlu-A; DmGlu-RA; DmGluA; DmGluAR; DmGluR; dmGluRA; DmGluRA; DmGluR[[A]]; DmGlu[[A]]R; FBgn0019985; Glu-RA; GluR; mGLuR; mGlurA; mGluRA
Summary: Enables cholesterol binding activity; glutamate binding activity; and group II metabotropic glutamate receptor activity. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; learning or memory; and synapse organization. Located in membrane raft and plasma membrane. Is expressed in several structures, including adult central brain intrinsic neurons; ellipsoid body layer; ganglia; neuromere; and synaptic neuropil domain. Orthologous to several human genes including GRM3 (glutamate metabotropic receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 102F1-102F3; 4-0 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (936819..949441)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (957445..970067)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Small-molecule screening in aged Drosophila identifies mGluR as a regulator of age-related sleep impairment.
Title: Small-molecule screening in aged Drosophila identifies mGluR as a regulator of age-related sleep impairment.
loss of the conserved proline-rich PPXXF sequence on DmGluRA reduces Homer/DmGluRA associations and significantly reduces sleep amount. Thus, identifying a conserved mechanism of synaptic plasticity in Drosophila and demonstrating that the interaction of Homer with DmGluRA is necessary to promote sleep.
Title: Genetic disruption of the putative binding site for Homer on DmGluRA reduces sleep in Drosophila.
mGluR signaling regulates sleep/wake in a manner that is relevant to the aging process.
Title: Loss of DmGluRA exacerbates age-related sleep disruption and reduces lifespan.
Drosophila master pacemaker neurons perceive both PDF and glutamate via PDFR and mGluRA G-protein coupled receptors that increase or decrease intracellular cAMP, respectively in response to light stimulus.
Title: Differentially timed extracellular signals synchronize pacemaker neuron clocks.
DmGluRA mutations increase neuronal excitability by preventing PI3 kinase (PI3K) activation and consequently hyperactivating the transcription factor Foxo
Title: A PI3-kinase-mediated negative feedback regulates neuronal excitability.
Metabotropic glutamate receptor A (mGluRA) and fragile X mental retardation (Fmr) protein genetically interact in behavioral movement regulation.
Title: Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling.
we report DmGluRA expression in most neuropile areas in both larvae and adults, but not in the lobes of the mushroom bodies
Title: Widespread brain distribution of the Drosophila metabotropic glutamate receptor.
Two roles were found for DmGluRA in presynaptic mechanisms: (1) modulation of presynaptic excitability properties important for control of activity-dependent neurotransmitter release and (2) modulation of synaptic architecture.
Title: The Drosophila metabotropic glutamate receptor DmGluRA regulates activity-dependent synaptic facilitation and fine synaptic morphology.
sterol-rich lipid rafts act as positive allosteric regulators of DmGluRA.
Title: Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts.
transgenic flies expressing a number of GPCRs in the photoreceptor cells
Title: Functional reconstitution of purified metabotropic glutamate receptor expressed in the fly eye.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 937640-938062 mobile_element_type = transposon:INE-1{}2772
Loc: 938147-938265 mobile_element_type = transposon:INE-1{}2774
Loc: 939882-940079 mobile_element_type = transposon:INE-1{}5429
Loc: 947634-947690 mobile_element_type = transposon:INE-1{}2897

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables cholesterol binding	IDA Inferred from Direct Assay more info	PubMed
enables glutamate binding	IDA Inferred from Direct Assay more info	PubMed
enables glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables group II metabotropic glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables group II metabotropic glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled receptor homodimeric complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metabotropic glutamate receptor

Names: CG11144-PA; CG11144-PB; CG11144-PC; CG11144-PD; mGluR-PA; mGluR-PB; mGluR-PC; mGluR-PD; mGluRA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

936819..949441

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272147.1 → NP_001259076.1 metabotropic glutamate receptor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259076.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91685, Q9V485

UniProtKB/TrEMBL

L0MPZ9

Conserved Domains (4) summary

pfam00003
Location:638 → 873

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:72 → 518

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:557 → 604

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:43 → 542

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
NM_079900.3 → NP_524639.2 metabotropic glutamate receptor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524639.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P91685, Q9V485

UniProtKB/TrEMBL

L0MPZ9

Related

FBpp0088248

Conserved Domains (4) summary

pfam00003
Location:638 → 873

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:72 → 518

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:557 → 604

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:43 → 542

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
NM_001297789.1 → NP_001284718.1 metabotropic glutamate receptor, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284718.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JBI2

Conserved Domains (2) summary

pfam01094
Location:72 → 236

ANF_receptor; Receptor family ligand binding region

cl10011
Location:43 → 229

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
NM_001272148.1 → NP_001259077.1 metabotropic glutamate receptor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259077.1

Status: REVIEWED

UniProtKB/TrEMBL

C5WLT4

Conserved Domains (2) summary

pfam01094
Location:72 → 518

ANF_receptor; Receptor family ligand binding region

cl10011
Location:43 → 532

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily