U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tsf1 Transferrin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32821, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tsf1provided by FlyBase
    Official Full Name
    Transferrin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0022355
    Locus tag
    Dmel_CG6186
    See related
    AllianceGenome:FB:FBgn0022355
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    143958_at; anon-EST:Posey265; CG6186; Dmel\CG6186; lincRNA.S9601; Tf; Trf; tsf1; TSF1
    Summary
    Predicted to enable iron ion binding activity. Involved in olfactory behavior. Located in extracellular region and plasma membrane. Is expressed in several structures, including adult head; adult heart; adult hemolymph; gonad; and nephrocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tsf1 in Genome Data Viewer
    Location:
    17A9-17A9; 1-60 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18387084..18390344)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18281117..18284377)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Coat Protein (coatomer) beta Neighboring gene 5' nucleotidase B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Drosophila melanogaster transferrin. Cloning, deduced protein sequence, expression during the life cycle, gene localization and up-regulation on bacterial infection. Yoshiga T, et al. Eur J Biochem, 1999 Mar. PMID 10095776
    2. Iron binding and release properties of transferrin-1 from Drosophila melanogaster and Manduca sexta: Implications for insect iron homeostasis. Weber JJ, et al. Insect Biochem Mol Biol, 2020 Oct. PMID 32735914, Free PMC Article
    3. Phenotypic analyses, protein localization, and bacteriostatic activity of Drosophila melanogaster transferrin-1. Weber JJ, et al. Insect Biochem Mol Biol, 2022 Aug. PMID 35781032, Free PMC Article
    4. The iron transporter Transferrin 1 mediates homeostasis of the endosymbiotic relationship between Drosophila melanogaster and Spiroplasma poulsonii. Marra A, et al. Microlife, 2021. PMID 37223258, Free PMC Article
    5. Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster. Lopez TE, et al. Arch Insect Biochem Physiol, 2016 Dec. PMID 27696504, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Evi5 is a critical regulator of intracellular iron transport via transferrin and ferritin interactions.
      Title: Drosophila Evi5 is a critical regulator of intracellular iron transport via transferrin and ferritin interactions.
    2. Transferrin1 modulates rotenone-induced Parkinson's disease through affecting iron homeostasis in Drosophila melanogaster.
      Title: Transferrin1 modulates rotenone-induced Parkinson's disease through affecting iron homeostasis in Drosophila melanogaster.
    3. Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster.
      Title: Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to fungus HEP PubMed 
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transferrin 1
    Names
    CG6186-PA
    CG6186-PC
    DTAF-transferrin
    Transferrin1
    Tsf1-PA
    Tsf1-PC
    transferrin
    transferrin precursor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18387084..18390344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298475.1 → NP_001285404.1  transferrin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285404.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNH0, O97355, Q9VWV6
      Conserved Domains (3) summary
      smart00094
      Location:384 → 614
      TR_FER; Transferrin
      cd13529
      Location:34 → 302
      PBP2_transferrin; Transferrin family of the type 2 periplasmic-binding protein superfamily
      cl21456
      Location:384 → 615
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    2. NM_078677.3 → NP_523401.2  transferrin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523401.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNH0, O97355, Q9VWV6
      Related
      FBpp0074331
      Conserved Domains (3) summary
      smart00094
      Location:384 → 614
      TR_FER; Transferrin
      cd13529
      Location:34 → 302
      PBP2_transferrin; Transferrin family of the type 2 periplasmic-binding protein superfamily
      cl21456
      Location:384 → 615
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97355 O97355
    Q9VWV6 Q9VWV6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous