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    ec echinus [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31339, updated on 9-Dec-2024

    Summary

    Official Symbol
    ecprovided by FlyBase
    Official Full Name
    echinusprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000542
    Locus tag
    Dmel_CG2904
    See related
    AllianceGenome:FB:FBgn0000542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2904; Dmel\CG2904; Ec; EG:EG0002.3; Q1W9Q0
    Summary
    Enables protein phosphatase 1 binding activity. Involved in compound eye retinal cell programmed cell death; ommatidial rotation; and positive regulation of compound eye retinal cell programmed cell death. Is expressed in cone cell; interommatidial precursor cell; primary pigment cell; and retina. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to several human genes including USP54 (ubiquitin specific peptidase 54). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    Location:
    3F2-3F3; 1-5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3811698..3857621)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3705731..3751654)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44118 Neighboring gene Hsc/Hsp70-interacting protein Neighboring gene forkhead domain 3F Neighboring gene transfer RNA:Glutamine-CTG 2-1 Neighboring gene transfer RNA:Proline-CGG 3-1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA on the X 1 Neighboring gene yin Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase AC39 subunit 1

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    echinus
    Names
    CG2904-PA
    CG2904-PB
    CG2904-PC
    ec-PA
    ec-PB
    ec-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3811698..3857621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130722.4NP_570078.2  echinus, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570078.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1W9Q0, Q7K7E6
      Conserved Domains (3) summary
      cd02257
      Location:164391
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cl02553
      Location:75220
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:76391
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. NM_166992.3NP_726893.2  echinus, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726893.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77283, Q6PV58, Q7K7E6
      Conserved Domains (2) summary
      cd02257
      Location:130357
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:49357
      UCH; Ubiquitin carboxyl-terminal hydrolase
    3. NM_001103407.3NP_001096877.1  echinus, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096877.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1W9P9, Q7K7E6
      Conserved Domains (1) summary
      cd02257
      Location:183410
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...