cv crossveinless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cvprovided by FlyBase
Official Full Name: crossveinlessprovided by FlyBase
Primary source: FLYBASE:FBgn0000394
Locus tag: Dmel_CG12410
See related: AllianceGenome:FB:FBgn0000394
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12410; Cv; cv-1; Dmel\CG12410; tsg2; Tsg2
Summary: Enables BMP binding activity. Involved in positive regulation of muscle organ development; regulation of BMP signaling pathway; and regulation of imaginal disc-derived wing vein specification. Located in extracellular space. Is expressed in organism; presumptive wing vein; pupal cuticle; tracheal pit; and wing disc. Orthologous to human TWSG1 (twisted gastrulation BMP signaling modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5690002..5693084)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5584035..5587117)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

an upstream regulatory region of cv is directly responsive to the basic, helix-loop-helix-PAS domain factors Trachealess (Trh) and Tango (Tgo), that function to specify tracheal fate.
Title: Crossveinless is a direct transcriptional target of Trachealess and Tango in Drosophila tracheal precursor cells.
Sog and Cv promote BMP signaling by transporting a BMP heterodimer from the longitudinal veins into the crossvein regions.
Title: The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing.
crossveinless represents a subgroup of the Twisted gastrulation-like bone morphogenetic protein-modulating proteins
Title: crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables BMP binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

Names: CG12410-PA; CG12410-PB; CG12410-PC; crossvein; cv-PA; cv-PB; cv-PC; twisted gastrulation 2

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