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    Ca-alpha1T Ca[2+]-channel protein alpha[[1]] subunit T [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31550, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ca-alpha1Tprovided by FlyBase
    Official Full Name
    Ca[2+]-channel protein alpha[[1]] subunit Tprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264386
    Locus tag
    Dmel_CG15899
    See related
    AllianceGenome:FB:FBgn0264386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha1T; alphaIT; ca-alpha1T; Ca-alphaT-RC; Ca1G; Caalpha1T; cat; CG12544; CG15899; CG4222; DmalphaG; Dmca1G; Dmel\CG15899; T-type Ca[2+]
    Summary
    Enables low voltage-gated calcium channel activity. Involved in calcium ion transmembrane transport via low voltage-gated calcium channel. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in several structures, including adult brain; adult central complex; adult head; adult mushroom body; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in cerebellar ataxia type 42; childhood absence epilepsy; primary hyperaldosteronism; and schizophrenia. Orthologous to several human genes including CACNA1H (calcium voltage-gated channel subunit alpha1 H) and CACNA1I (calcium voltage-gated channel subunit alpha1 I). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ca-alpha1T in Genome Data Viewer
    Location:
    5D5-5D7; 1-15 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6104085..6192483, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5998118..6086516, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44959 Neighboring gene raptor Neighboring gene Multiple inositol polyphosphate phosphatase 2 Neighboring gene Neprilysin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cav3-type α1T calcium channels mediate transient calcium currents that regulate repetitive firing in Drosophila antennal lobe PNs. Iniguez J, et al. J Neurophysiol, 2013 Oct. PMID 23864373, Free PMC Article
    2. Ca-α1T, a fly T-type Ca2+ channel, negatively modulates sleep. Jeong K, et al. Sci Rep, 2015 Dec 9. PMID 26647714, Free PMC Article
    3. Editing efficiency of a Drosophila gene correlates with a distant splice site selection. Agrawal R, et al. RNA, 2005 May. PMID 15840811, Free PMC Article
    4. Conservation of cardiac L-type Ca(2+) channels and their regulation in Drosophila: A novel genetically-pliable channelopathic model. Limpitikul WB, et al. J Mol Cell Cardiol, 2018 Jun. PMID 29684406, Free PMC Article
    5. Ca(v)2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons. Ryglewski S, et al. J Physiol, 2012 Feb 15. PMID 22183725, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c6179013-6171638 mobile_element_type = transposon:Quasimodo{}68

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables low voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables low voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport via low voltage-gated calcium channel IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ca[2+]-channel protein alpha[[1]] subunit T
    Names
    CG15899-PB
    CG15899-PC
    CG15899-PD
    CG15899-PE
    CG15899-PF
    Ca-alpha1T-PB
    Ca-alpha1T-PC
    Ca-alpha1T-PD
    Ca-alpha1T-PE
    Ca-alpha1T-PF
    Ca1G

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6104085..6192483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272338.1 → NP_001259267.1  Ca[2+]-channel protein alpha[[1]] subunit T, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259267.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGH9
      Conserved Domains (1) summary
      pfam00520
      Location:1261 → 1495
      Ion_trans; Ion transport protein

    2. NM_001258616.1 → NP_001245545.1  Ca[2+]-channel protein alpha[[1]] subunit T, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245545.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDQ0
      Conserved Domains (1) summary
      pfam00520
      Location:1243 → 1477
      Ion_trans; Ion transport protein

    3. NM_001258615.1 → NP_001245544.1  Ca[2+]-channel protein alpha[[1]] subunit T, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NGR9
      Conserved Domains (1) summary
      pfam00520
      Location:1240 → 1457
      Ion_trans; Ion transport protein

    4. NM_001103419.2 → NP_001096889.1  Ca[2+]-channel protein alpha[[1]] subunit T, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096889.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUY8
      Conserved Domains (1) summary
      pfam00520
      Location:1248 → 1482
      Ion_trans; Ion transport protein

    5. NM_132068.3 → NP_572296.2  Ca[2+]-channel protein alpha[[1]] subunit T, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572296.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W433
      Conserved Domains (1) summary
      pfam00520
      Location:1248 → 1465
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUY8 A8JUY8
    M9NDQ0 M9NDQ0
    M9NGR9 M9NGR9
    M9PGH9 M9PGH9
    Q963J0 Q963J0
    Q963J1 Q963J1
    Q963J2 Q963J2
    Q967R3 Q967R3
    Q9W433 Q9W433

    Gene LinkOut

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