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    mamo maternal gene required for meiosis [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mamoprovided by FlyBase
    Official Full Name
    maternal gene required for meiosisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267033
    Locus tag
    Dmel_CG45477
    See related
    AllianceGenome:FB:FBgn0267033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11071; CG11072; CG11075; CG11082; CG32606; CG32611; CG34346; CG44132; CG45477; CR44656; Dmel\CG45477; lincRNA.990; Mamo
    Old locus tag
    CG11072; CG32611; Dmel_CG11071; Dmel_CG11072; Dmel_CG32606; Dmel_CG32611; Dmel_CG34346; Dmel_CG44132
    Summary
    Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in several processes, including female meiotic nuclear division; regulation of transcription by RNA polymerase II; and sperm DNA decondensation. Located in cytoplasm and nuclear chromosome. Is expressed in embryonic/larval crystal cell and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mamo in Genome Data Viewer
    Location:
    12C7-12D1; 1-47 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13846116..13990527, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13740149..13884560, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene AMP deaminase Neighboring gene Ajuba LIM protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44655 Neighboring gene bendless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Binding of Drosophila maternal Mamo protein to chromatin and specific DNA sequences. Hira S, et al. Biochem Biophys Res Commun, 2013 Aug 16. PMID 23876313
    2. Isoforms of terminal selector Mamo control axon guidance during adult Drosophila memory center construction via Semaphorin-1a. Chu SY, et al. Dev Biol, 2024 Nov. PMID 38906235
    3. Mamo decodes hierarchical temporal gradients into terminal neuronal fate. Liu LY, et al. Elife, 2019 Sep 23. PMID 31545163, Free PMC Article
    4. A truncated form of a transcription factor Mamo activates vasa in Drosophila embryos. Nakamura S, et al. Commun Biol, 2019. PMID 31799425, Free PMC Article
    5. Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival. Pfeifer K, et al. Dis Model Mech, 2022 Aug 1. PMID 35972154, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Isoforms of terminal selector Mamo control axon guidance during adult Drosophila memory center construction via Semaphorin-1a.
      Title: Isoforms of terminal selector Mamo control axon guidance during adult Drosophila memory center construction via Semaphorin-1a.
    2. Our results suggest that Mamo plays a role in regulating chromatin structure in PGCs.
      Title: Binding of Drosophila maternal Mamo protein to chromatin and specific DNA sequences.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c13941241-13938036 mobile_element_type = transposon:I{}120

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm DNA decondensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    maternal gene required for meiosis
    Names
    CG45477-PC
    CG45477-PD
    CG45477-PE
    CG45477-PF
    CG45477-PG
    CG45477-PH
    CG45477-PI
    mamo-PC
    mamo-PD
    mamo-PE
    mamo-PF
    mamo-PG
    mamo-PH
    mamo-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13846116..13990527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132704.4 → NP_572932.2  maternal gene required for meiosis, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572932.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY72, Q9VY73
      Conserved Domains (5) summary
      smart00225
      Location:32 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:1471 → 1491
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1469 → 1491
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:21 → 118
      BTB; BTB/POZ domain
      pfam13465
      Location:1511 → 1536
      zf-H2C2_2; Zinc-finger double domain

    2. NM_167387.5 → NP_727743.3  maternal gene required for meiosis, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727743.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY72, Q9VY73
      Conserved Domains (5) summary
      smart00225
      Location:32 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:1471 → 1491
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1469 → 1491
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:21 → 118
      BTB; BTB/POZ domain
      pfam13465
      Location:1511 → 1536
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001201660.3 → NP_001188589.1  maternal gene required for meiosis, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJM9, Q0EEE4
      Conserved Domains (4) summary
      smart00225
      Location:32 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:1016 → 1036
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21 → 118
      BTB; BTB/POZ domain
      pfam13465
      Location:1028 → 1053
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001258732.2 → NP_001245661.1  maternal gene required for meiosis, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEG1, Q0EEE4
      Conserved Domains (5) summary
      smart00225
      Location:32 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:1010 → 1030
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21 → 118
      BTB; BTB/POZ domain
      pfam12756
      Location:1010 → 1065
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:1050 → 1075
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001272610.2 → NP_001259539.1  maternal gene required for meiosis, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259539.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJM9, Q0EEE4
      Conserved Domains (4) summary
      smart00225
      Location:32 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:1016 → 1036
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21 → 118
      BTB; BTB/POZ domain
      pfam13465
      Location:1028 → 1053
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001258733.1 → NP_001245662.1  maternal gene required for meiosis, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEG1, Q0EEE4
      Conserved Domains (5) summary
      smart00225
      Location:32 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:1010 → 1030
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21 → 118
      BTB; BTB/POZ domain
      pfam12756
      Location:1010 → 1065
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:1050 → 1075
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001103508.4 → NP_001096978.1  maternal gene required for meiosis, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096978.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUK0, Q4V730
      Conserved Domains (2) summary
      smart00225
      Location:32 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:21 → 118
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NEG1 M9NEG1
    M9PJM9 M9PJM9
    Q0EEE4 Q0EEE4
    Q9VY72 Q9VY72

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