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    CG14411 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32408, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14411provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030582
    Locus tag
    Dmel_CG14411
    See related
    AllianceGenome:FB:FBgn0030582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14411; MTMR10/11/12
    Summary
    Involved in defense response to Gram-negative bacterium. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including MTMR10 (myotubularin related protein 10) and MTMR12 (myotubularin related protein 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14411 in Genome Data Viewer
    Location:
    12F5-12F5; 1-49 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14832647..14836262)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14726680..14730295)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45522 Neighboring gene rutabaga Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutaredoxin 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myotubularin phosphatases: policing 3-phosphoinositides. Robinson FL, et al. Trends Cell Biol, 2006 Aug. PMID 16828287
    2. Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Jean S, et al. Mol Biol Cell, 2012 Jul. PMID 22648168, Free PMC Article
    3. Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection. Berkey CD, et al. Cell Microbiol, 2009 Mar. PMID 19046341, Free PMC Article
    4. Expansion and evolution of insect GMC oxidoreductases. Iida K, et al. BMC Evol Biol, 2007 May 11. PMID 17498303, Free PMC Article
    5. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables phosphatase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables protein tyrosine phosphatase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14411-PA
    CG14411-PB
    CG14411-PC
    CG14411-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14832647..14836262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132744.3 → NP_572972.1  uncharacterized protein Dmel_CG14411, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572972.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XY44, Q9VY15
      Related
      FBpp0073763
      Conserved Domains (3) summary
      pfam12578
      Location:666 → 732
      3-PAP; Myotubularin-associated protein
      cl17171
      Location:114 → 225
      PH-like; Pleckstrin homology-like domain
      cl21483
      Location:400 → 587
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_206713.3 → NP_996436.1  uncharacterized protein Dmel_CG14411, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996436.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XY44, Q9VY15
      Conserved Domains (3) summary
      pfam12578
      Location:666 → 732
      3-PAP; Myotubularin-associated protein
      cl17171
      Location:114 → 225
      PH-like; Pleckstrin homology-like domain
      cl21483
      Location:400 → 587
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    3. NM_001169285.2 → NP_001162756.1  uncharacterized protein Dmel_CG14411, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XY44, Q9VY15
      Conserved Domains (3) summary
      pfam12578
      Location:666 → 732
      3-PAP; Myotubularin-associated protein
      cl17171
      Location:114 → 225
      PH-like; Pleckstrin homology-like domain
      cl21483
      Location:400 → 587
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    4. NM_001169286.2 → NP_001162757.1  uncharacterized protein Dmel_CG14411, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162757.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XY44, Q9VY15
      Conserved Domains (3) summary
      pfam12578
      Location:666 → 732
      3-PAP; Myotubularin-associated protein
      cl17171
      Location:114 → 225
      PH-like; Pleckstrin homology-like domain
      cl21483
      Location:400 → 587
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2XY44 Q2XY44
    Q8SWS5 Q8SWS5
    Q9VY15 Q9VY15

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