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    Lsd-2 Lipid storage droplet-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32437, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lsd-2provided by FlyBase
    Official Full Name
    Lipid storage droplet-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0030608
    Locus tag
    Dmel_CG9057
    See related
    AllianceGenome:FB:FBgn0030608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    145098_at; CG9057; Dmel\CG9057; dmPLIN2; DmPLIN2; dPlin2; LSD; lsd-2; LSD-2; lsd2; Lsd2; LSD2; LSP-2; plin2; Plin2; PLIN2
    Summary
    Involved in several processes, including lipid droplet formation; lipid droplet transport along microtubule; and positive regulation of sequestering of triglyceride. Located in cytosol and lipid droplet. Is expressed in several structures, including adult brain; adult brain cell body rind; epithelium; fat body; and germline cell. Used to study metabolic dysfunction-associated steatotic liver disease and obesity. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 4 and obesity. Orthologous to several human genes including PLIN1 (perilipin 1) and PLIN2 (perilipin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lsd-2 in Genome Data Viewer
    Location:
    13A8-13A9; 1-49 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15069127..15076220, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14963160..14970253, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) B18 subunit Neighboring gene opossum Neighboring gene doppelganger von brummer Neighboring gene long non-coding RNA:CR44662 Neighboring gene long non-coding RNA:CR44661 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of fat storage by a Drosophila PAT domain protein. Grönke S, et al. Curr Biol, 2003 Apr 1. PMID 12676093
    2. Food memory circuits regulate eating and energy balance. Pardo-Garcia TR, et al. Curr Biol, 2023 Jan 23. PMID 36528025, Free PMC Article
    3. Ensheathing glia promote increased lifespan and healthy brain aging. Sheng L, et al. Aging Cell, 2023 May. PMID 36840361, Free PMC Article
    4. Purification and characterization of recombinant lipid storage protein-2 from Drosophila melanogaster. Arrese EL, et al. Protein Pept Lett, 2008. PMID 18991782, Free PMC Article
    5. Loss of swiss cheese in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in Drosophila Brain. Melentev PA, et al. Int J Mol Sci, 2021 Jul 31. PMID 34361042, Free PMC Article

    See all (168) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle.
      Title: Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle.
    2. An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase.
      Title: An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase.
    3. Functional Characterization of Gomisin N in High-Fat-Induced Drosophila Obesity Models.
      Title: Functional Characterization of Gomisin N in High-Fat-Induced Drosophila Obesity Models.
    4. Lsd-2-knockdown up-regulated the expression of the dFoxO transcription target reaper, which constitutes a pro-apoptosis gene. This study provides the first evidence that Lsd-2-knockdown causes cell death mediated by dfoxO.
      Title: LSD-2 dysfunction induces dFoxO-dependent cell death in the wing of Drosophila melanogaster.
    5. that HDAC6 is associated physically with the chaperone protein dHsc4/Hsc70 to maintain the proteostasis of PLIN2
      Title: HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila.
    6. Perilipin homologus, LSD2 plays a role in sleep regulation and prevents learning impariment following sleep loss.
      Title: The perilipin homologue, lipid storage droplet 2, regulates sleep homeostasis and prevents learning impairments following sleep loss.
    7. Lsd-2 is expressed and controls lipid storage in wing imaginal discs.
      Title: Drosophila Lipid Storage Droplet 2 gene (Lsd-2) is expressed and controls lipid storage in wing imaginal discs.
    8. LSD2 regulates both lipid metabolism and transport along microtubules in embryos.
      Title: Regulation of lipid-droplet transport by the perilipin homolog LSD2.
    9. Lsd2 has an evolutionarily conserved function in lipid metabolism
      Title: Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism.
    10. Lsd2, one of only two PAT domain-encoding genes in the Drosophila genome acts in a Perilipin-like manner, suggesting that components regulating homeostasis of lipid-based energy storage at the lipid droplet membrane are evolutionarily conserved.
      Title: Control of fat storage by a Drosophila PAT domain protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid droplet formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid droplet organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid droplet transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid storage IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sequestering of triglyceride IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of sequestering of triglyceride IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sequestering of triglyceride IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipid storage droplet-2
    Names
    CG9057-PA
    CG9057-PB
    CG9057-PD
    CG9057-PE
    CG9057-PF
    Lipid-storage Droplet-2
    Lsd-2-PA
    Lsd-2-PB
    Lsd-2-PD
    Lsd-2-PE
    Lsd-2-PF
    Perilipin2
    lipid storage droplet 2
    lipid storage droplet 2 gene
    lipid storage droplet protein 2
    perilipin
    perilipin-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15069127..15076220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298333.1 → NP_001285262.1  lipid storage droplet-2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285262.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JKC1
      Conserved Domains (1) summary
      pfam03036
      Location:40 → 200
      Perilipin; Perilipin family

    2. NM_001042811.2 → NP_001036276.1  lipid storage droplet-2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036276.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHS7
      Conserved Domains (1) summary
      pfam03036
      Location:40 → 270
      Perilipin; Perilipin family

    3. NM_001042812.2 → NP_001036277.2  lipid storage droplet-2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036277.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHS6
      Conserved Domains (1) summary
      pfam03036
      Location:40 → 200
      Perilipin; Perilipin family

    4. NM_132768.3 → NP_572996.1  lipid storage droplet-2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572996.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VXY7
      Related
      FBpp0073784
      Conserved Domains (1) summary
      pfam03036
      Location:40 → 287
      Perilipin; Perilipin family

    5. NM_001298332.1 → NP_001285261.1  lipid storage droplet-2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JKC1
      Conserved Domains (1) summary
      pfam03036
      Location:40 → 200
      Perilipin; Perilipin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KHS6 Q0KHS6
    Q0KHS7 Q0KHS7
    Q9VXY7.1 Q9VXY7
    X2JKC1 X2JKC1

    Gene LinkOut

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