mthl1 methuselah-like 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mthl1provided by FlyBase
Official Full Name: methuselah-like 1provided by FlyBase
Primary source: FLYBASE:FBgn0030766
Locus tag: Dmel_CG4521
See related: AllianceGenome:FB:FBgn0030766
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.22; anon-WO0170980.23; CG4521; Dmel\CG4521; mist; Mist; Mth-1
Summary: Enables G protein-coupled receptor activity. Involved in several processes, including mesectoderm development; mesoderm migration involved in gastrulation; and regulation of myosin II filament organization. Predicted to be located in membrane. Is expressed in several structures, including amnioproctodeal invagination; cercus; embryonic/larval gut; epithelium; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 14F4-14F5; 1-54 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (16640968..16650309)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (16535001..16544342)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mthl1, a potential Drosophila homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies.
Title: mthl1, a potential Drosophila homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in actin-mediated cell contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	ISS Inferred from Sequence or Structural Similarity more info
involved_in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myosin II filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in wing disc morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: methuselah-like 1

Names: CG4521-PA; CG4521-PB; Methuselah-like 1; mesoderm-invagination signal transducer; mist; mth-like 1; mthl1-PA; mthl1-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

16640968..16650309

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298411.1 → NP_001285340.1 methuselah-like 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285340.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VXD9

UniProtKB/TrEMBL

X2JC86

Conserved Domains (1) summary

cl21561
Location:329 → 579

7tm_4; Olfactory receptor
NM_132912.2 → NP_573140.1 methuselah-like 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_573140.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VXD9

UniProtKB/TrEMBL

X2JC86

Related

FBpp0074089

Conserved Domains (1) summary

cl21561
Location:329 → 579

7tm_4; Olfactory receptor