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    RhoGAP18B Rho GTPase activating protein at 18B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32898, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoGAP18Bprovided by FlyBase
    Official Full Name
    Rho GTPase activating protein at 18Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261461
    Locus tag
    Dmel_CG42274
    See related
    AllianceGenome:FB:FBgn0261461
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5-131; CG17015; CG42274; CG7481; CG7502; CG7531; Dmel\CG42274; whir
    Old locus tag
    Dmel_CG7481; Dmel_CG7502
    Summary
    Enables GTPase activator activity and small GTPase binding activity. Involved in actin cytoskeleton organization. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including adult central complex; adult gnathal ganglion; adult mushroom body; head epidermis primordium; and organism subdivision. Used to study alcohol use disorder. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See RhoGAP18B in Genome Data Viewer
    Location:
    18A3-18A4; 1-62 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19136107..19167082, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19030140..19061115, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45711 Neighboring gene Odorant-binding protein 18a Neighboring gene mir-4959 stem loop Neighboring gene Innexin 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: actin or reactin'? Rothenfluh A, et al. Curr Opin Neurobiol, 2013 Aug. PMID 23428655, Free PMC Article
    2. Oviposition preference for and positional avoidance of acetic acid provide a model for competing behavioral drives in Drosophila. Joseph RM, et al. Proc Natl Acad Sci U S A, 2009 Jul 7. PMID 19541615, Free PMC Article
    3. Drosophila RhoGAP18B regulates actin cytoskeleton during border cell migration. Lei F, et al. PLoS One, 2023. PMID 36662713, Free PMC Article
    4. The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. Gonzalez DA, et al. Mol Psychiatry, 2018 Mar. PMID 28607459, Free PMC Article
    5. Preferential ethanol consumption in Drosophila models features of addiction. Devineni AV, et al. Curr Biol, 2009 Dec 29. PMID 20005106, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila RhoGAP18B regulates actin cytoskeleton during border cell migration.
      Title: Drosophila RhoGAP18B regulates actin cytoskeleton during border cell migration.
    2. Results suggest that the RhoGAP18B-PA isoform mainly inactivates Cdc42, while PC and PD suppress Rac1 and Rho1 to activate cofilin.
      Title: RhoGAP18B Isoforms Act on Distinct Rho-Family GTPases and Regulate Behavioral Responses to Alcohol via Cofilin.
    3. Data show that distinct RhoGAPs, encoded by the same gene, regulate different manifestations of acute ethanol intoxication.
      Title: Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein at 18B
    Names
    CG42274-PB
    CG42274-PC
    CG42274-PD
    CG42274-PF
    CG42274-PH
    RhoGAP18B-PB
    RhoGAP18B-PC
    RhoGAP18B-PD
    RhoGAP18B-PF
    RhoGAP18B-PH
    white rabbit
    whiterabbit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19136107..19167082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133124.4 → NP_573352.2  Rho GTPase activating protein at 18B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573352.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q00IM9, Q9VWL7
      Conserved Domains (1) summary
      pfam00620
      Location:1141 → 1289
      RhoGAP; RhoGAP domain

    2. NM_001144748.2 → NP_001138220.1  Rho GTPase activating protein at 18B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138220.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q00IN0
      Conserved Domains (1) summary
      pfam00620
      Location:576 → 724
      RhoGAP; RhoGAP domain

    3. NM_001298497.1 → NP_001285426.1  Rho GTPase activating protein at 18B, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RJ6, Q9VWL9
      Conserved Domains (1) summary
      pfam00620
      Location:292 → 440
      RhoGAP; RhoGAP domain

    4. NM_001144749.2 → NP_001138221.1  Rho GTPase activating protein at 18B, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RJ6, Q9VWL9
      Conserved Domains (1) summary
      pfam00620
      Location:292 → 440
      RhoGAP; RhoGAP domain

    5. NM_133123.2 → NP_573351.1  Rho GTPase activating protein at 18B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573351.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RJ6, Q9VWL9
      Related
      FBpp0288897
      Conserved Domains (1) summary
      pfam00620
      Location:292 → 440
      RhoGAP; RhoGAP domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00IM9 Q00IM9
    Q00IN0 Q00IN0
    Q9VWL7 Q9VWL7
    Q9VWL9 Q9VWL9

    Gene LinkOut

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