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    Tango14 Transport and Golgi organization 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33298, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tango14provided by FlyBase
    Official Full Name
    Transport and Golgi organization 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0031312
    Locus tag
    Dmel_CG4775
    See related
    AllianceGenome:FB:FBgn0031312
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD10843; CG4775; Dmel\CG4775; l(2)k00619; Tango 14; TANGO14
    Summary
    Predicted to enable transferase activity, transferring alkyl or aryl (other than methyl) groups. Predicted to contribute to dehydrodolichyl diphosphate synthase activity. Involved in protein secretion. Located in endoplasmic reticulum. Is expressed in adult head. Used to study Parkinson's disease and epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tango14 in Genome Data Viewer
    Location:
    21F1-21F1; 2-2 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1158661..1160220)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1158661..1160220)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lethal (2) 10685 Neighboring gene Transcription factor B4 Neighboring gene Vacuolar protein sorting 29 Neighboring gene capulet Neighboring gene antisense RNA:CR43767 Neighboring gene uncharacterized protein Neighboring gene Integrator 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of Drosophila NUS1 results in cholesterol accumulation and Parkinson's disease-related neurodegeneration. Xue J, et al. FASEB J, 2022 Jul. PMID 35695805
    2. Coding mutations in NUS1 contribute to Parkinson's disease. Guo JF, et al. Proc Natl Acad Sci U S A, 2018 Nov 6. PMID 30348779, Free PMC Article
    3. NUS1 Variants Cause Lennox-Gastaut Syndrome Related to Unfolded Protein Reaction Activation. Shen NX, et al. Mol Neurobiol, 2024 Nov. PMID 38520610
    4. Efficient strategies based on behavioral and electrophysiological methods for epilepsy-related gene screening in the Drosophila model. Liu CQ, et al. Front Mol Neurosci, 2023. PMID 37152436, Free PMC Article
    5. Knockdown of Dehydrodolichyl Diphosphate Synthase in the Drosophila Retina Leads to a Unique Pattern of Retinal Degeneration. Brandwine T, et al. Front Mol Neurosci, 2021. PMID 34290587, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NUS1 Variants Cause Lennox-Gastaut Syndrome Related to Unfolded Protein Reaction Activation.
      Title: NUS1 Variants Cause Lennox-Gastaut Syndrome Related to Unfolded Protein Reaction Activation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to dehydrodolichyl diphosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dolichol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of dehydrodolichyl diphosphate synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dehydrodolichyl diphosphate synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transport and golgi organization 14
    Names
    CG4775-PA
    CG4775-PB
    Tango14-PA
    Tango14-PB
    lethal (2) k00619
    NP_001259857.1
    NP_608577.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1158661..1160220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134733.3 → NP_608577.2  transport and golgi organization 14, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608577.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPX8
      Related
      FBpp0077626
      Conserved Domains (1) summary
      cl00230
      Location:78 → 277
      Cis_IPPS; Cis (Z)-Isoprenyl Diphosphate Synthases

    2. NM_001272928.1 → NP_001259857.1  transport and golgi organization 14, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPX8
      Conserved Domains (1) summary
      cl00230
      Location:78 → 277
      Cis_IPPS; Cis (Z)-Isoprenyl Diphosphate Synthases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95R38 Q95R38
    Q9VPX8 Q9VPX8

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