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    CG33298 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG33298provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032120
    Locus tag
    Dmel_CG33298
    See related
    AllianceGenome:FB:FBgn0032120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13112; CG18419; DmCG33298; Dmel\CG33298
    Summary
    Enables ATPase-coupled intramembrane lipid transporter activity. Involved in trans-Golgi network membrane organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; dorsal ectoderm; eye disc; hindgut anlage in statu nascendi; and larval central nervous system. Orthologous to several human genes including ATP10A (ATPase phospholipid transporting 10A (putative)) and ATP10D (ATPase phospholipid transporting 10D (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG33298 in Genome Data Viewer
    Location:
    30B5-30B10; 2-35 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9495474..9520696)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9495474..9520696)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43769 Neighboring gene GDP dissociation inhibitor Neighboring gene Organic anion transporting polypeptide 30B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functions of phospholipid flippases. Tanaka K, et al. J Biochem, 2011 Feb. PMID 21134888
    2. Modulation of alternative splicing by long-range RNA structures in Drosophila. Raker VA, et al. Nucleic Acids Res, 2009 Aug. PMID 19465384, Free PMC Article
    3. Extreme deformability of insect cell membranes is governed by phospholipid scrambling. Shiomi A, et al. Cell Rep, 2021 Jun 8. PMID 34107250
    4. Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes. Chow CY, et al. Proc Natl Acad Sci U S A, 2013 May 28. PMID 23667151, Free PMC Article
    5. P-type ATPases in Caenorhabditis and Drosophila: implications for evolution of the P-type ATPase subunit families with special reference to the Na,K-ATPase and H,K-ATPase subgroup. Okamura H, et al. J Membr Biol, 2003 Jan 1. PMID 12532273

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 9503225-9503351 mobile_element_type = transposon:INE-1{}6181

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ATPase-coupled intramembrane lipid transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to endoplasmic reticulum stress HMP PubMed 
    involved_in trans-Golgi network membrane organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG33298-PA
    CG33298-PB
    CG33298-PC
    CG33298-PD
    NP_001162919.1
    NP_001162920.1
    NP_995665.1
    NP_995666.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9495474..9520696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205944.3 → NP_995666.1  uncharacterized protein Dmel_CG33298, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTG6
      Conserved Domains (6) summary
      TIGR01652
      Location:250 → 1473
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:302 → 394
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:880 → 965
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:249 → 299
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1223 → 1468
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1177 → 1240
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_205943.3 → NP_995665.1  uncharacterized protein Dmel_CG33298, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTG5
      Conserved Domains (6) summary
      TIGR01652
      Location:250 → 1473
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:302 → 394
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:880 → 965
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:249 → 299
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1223 → 1468
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1177 → 1240
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    3. NM_001169448.2 → NP_001162919.1  uncharacterized protein Dmel_CG33298, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162919.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTG5
      Conserved Domains (6) summary
      TIGR01652
      Location:250 → 1473
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:302 → 394
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:880 → 965
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:249 → 299
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1223 → 1468
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1177 → 1240
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    4. NM_001169449.2 → NP_001162920.1  uncharacterized protein Dmel_CG33298, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162920.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTG5
      Conserved Domains (6) summary
      TIGR01652
      Location:250 → 1473
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:302 → 394
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:880 → 965
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:249 → 299
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1223 → 1468
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1177 → 1240
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTG5 Q7KTG5
    Q7KTG6 Q7KTG6
    Q95S66 Q95S66

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