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    CG31872 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34458, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG31872provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051872
    Locus tag
    Dmel_CG31872
    See related
    AllianceGenome:FB:FBgn0051872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17093; CG17101; Dmel\CG31872
    Summary
    Enables serine hydrolase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head; embryonic head sensory system; sensory nervous system primordium; and spermatozoon. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG31872 in Genome Data Viewer
    Location:
    32A2-32A2; 2-43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10639931..10643539)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10639931..10643539)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45351 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Using blocks of linked single nucleotide polymorphisms as highly polymorphic genetic markers for parentage analysis. Jones B, et al. Mol Ecol Resour, 2009 Mar. PMID 21564678
    2. Comparative phosphoproteomics reveal new candidates in the regulation of spermatogenesis of Drosophila melanogaster. Mao B, et al. Insect Sci, 2022 Dec. PMID 35271765
    3. Sperm competitive ability in Drosophila melanogaster associated with variation in male reproductive proteins. Fiumera AC, et al. Genetics, 2005 Jan. PMID 15466425, Free PMC Article
    4. Inference of positive and negative selection on the 5' regulatory regions of Drosophila genes. Kohn MH, et al. Mol Biol Evol, 2004 Feb. PMID 14660692
    5. Nonadaptive molecular evolution of seminal fluid proteins in Drosophila. Patlar B, et al. Evolution, 2021 Aug. PMID 34184267, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31872-PA
    CG31872-PB
    NP_001285806.1
    NP_723603.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10639931..10643539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298877.1 → NP_001285806.1  uncharacterized protein Dmel_CG31872, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKT1
      Conserved Domains (2) summary
      pfam04083
      Location:716 → 767
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:752 → 894
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_164937.3 → NP_723603.1  uncharacterized protein Dmel_CG31872, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723603.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKT1
      Related
      FBpp0079688
      Conserved Domains (2) summary
      pfam04083
      Location:716 → 767
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:752 → 894
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKT1 Q9VKT1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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