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    Lip2 Lipase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43980, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lip2provided by FlyBase
    Official Full Name
    Lipase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0024740
    Locus tag
    Dmel_CG17116
    See related
    AllianceGenome:FB:FBgn0024740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17116; dilp2; DILP2; Dmel\CG17116; Dmlip2; lip2
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lip2 in Genome Data Viewer
    Location:
    32A4-32A5; 2-43 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10701940..10709453, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10701940..10709453, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44181 Neighboring gene uncharacterized protein Neighboring gene Lipase 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44407 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster lipase homologs: a gene family with tissue and developmental specific expression. Pistillo D, et al. J Mol Biol, 1998 Mar 13. PMID 9566193
    2. Suppression of intestinal dysfunction in a Drosophila model of Parkinson's disease is neuroprotective. Fedele G, et al. Nat Aging, 2022 Apr. PMID 37117744
    3. Female sterile mutations and egg chamber development in Drosophila melanogaster. Gigliotti S, et al. Int J Dev Biol, 2000. PMID 11061421
    4. Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species. Mathew R, et al. Biogerontology, 2017 Feb. PMID 28101820
    5. Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. Dembeck LM, et al. Elife, 2015 Nov 14. PMID 26568309, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipase 2
    Names
    CG17116-PA
    CG17116-PB
    Lip2-PA
    Lip2-PB
    NP_001285812.1
    NP_524667.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10701940..10709453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298883.1 → NP_001285812.1  lipase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9C9
      Conserved Domains (2) summary
      pfam00561
      Location:35 → 345
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:12 → 54
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

    2. NM_079928.2 → NP_524667.1  lipase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524667.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKR5
      Related
      FBpp0079712
      Conserved Domains (2) summary
      PLN02872
      Location:24 → 407
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:48 → 90
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKR5 Q9VKR5
    X2J9C9 X2J9C9

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