nompB no mechanoreceptor potential B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nompBprovided by FlyBase
Official Full Name: no mechanoreceptor potential Bprovided by FlyBase
Primary source: FLYBASE:FBgn0016919
Locus tag: Dmel_CG12548
See related: AllianceGenome:FB:FBgn0016919
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 146590_s_at; CG12548; CG14465; CG15190; CG4137; Dmel\CG12548; IFT88; nomp; NompB; NOMPB; osm-5; OSM-5; Tg737
Summary: Predicted to enable kinesin binding activity. Involved in intraciliary transport; non-motile cilium assembly; and sensory perception of sound. Located in non-motile cilium. Orthologous to human IFT88 (intraflagellar transport 88). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (21578292..21589423, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (21578292..21589423, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

IFT88 maintains sensory function by localising signalling proteins along Drosophila cilia.
Title: IFT88 maintains sensory function by localising signalling proteins along Drosophila cilia.
NOMPB is required for the assembly of sensory cilia but not for the extension or function of the sperm flagellum.
Title: Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables kinesin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	ISM Inferred from Sequence Model more info	PubMed
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ciliary base	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
part_of intraciliary transport particle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of intraciliary transport particle B	ISS Inferred from Sequence or Structural Similarity more info
is_active_in non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

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