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    CG2070 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35706, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2070provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033203
    Locus tag
    Dmel_CG2070
    See related
    AllianceGenome:FB:FBgn0033203
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2070
    Summary
    Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Located in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2070 in Genome Data Viewer
    Location:
    43E8-43E8; 2-57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7661855..7663408)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3549360..3550913)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like 43a Neighboring gene uncharacterized protein Neighboring gene Retinol dehydrogenase 1 Neighboring gene Dynactin 4, p62 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster. Belyaeva OV, et al. Biochim Biophys Acta, 2009 Oct. PMID 19520149, Free PMC Article
    2. The Recent De Novo Origin of Protein C-Termini. Andreatta ME, et al. Genome Biol Evol, 2015 May 21. PMID 26002864, Free PMC Article
    3. Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa. Lehmann M, et al. Methods Mol Biol, 2019. PMID 30324448
    4. Heat-shock promoters: targets for evolution by P transposable elements in Drosophila. Walser JC, et al. PLoS Genet, 2006 Oct 6. PMID 17029562, Free PMC Article
    5. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2070-PA
    CG2070-PB
    NP_001260786.1
    NP_610308.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7661855..7663408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273857.1 → NP_001260786.1  uncharacterized protein Dmel_CG2070, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZG9, Q9V4Q1
      Conserved Domains (2) summary
      PRK06197
      Location:41 → 323
      PRK06197; short chain dehydrogenase; Provisional
      cl21454
      Location:43 → 317
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_136464.2 → NP_610308.2  uncharacterized protein Dmel_CG2070, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610308.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZG9, Q9V4Q1
      Related
      FBpp0087995
      Conserved Domains (2) summary
      PRK06197
      Location:41 → 323
      PRK06197; short chain dehydrogenase; Provisional
      cl21454
      Location:43 → 317
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MZG9 Q8MZG9

    Gene LinkOut

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