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    Den1 Deneddylase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Den1provided by FlyBase
    Official Full Name
    Deneddylase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033716
    Locus tag
    Dmel_CG8493
    See related
    AllianceGenome:FB:FBgn0033716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8493; DEN1; Dmel\CG8493
    Summary
    Enables cysteine-type deNEDDylase activity. Involved in positive regulation of apoptotic process and protein deneddylation. Is expressed in adult head. Orthologous to human SENP8 (SUMO peptidase family member, NEDD8 specific). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Den1 in Genome Data Viewer
    Location:
    48F10-48F10; 2-66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12337797..12339544)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8225302..8227049)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Histidine-GTG 2-1 pseudogene Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene anastral spindle 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster. Kim K, et al. Insect Sci, 2017 Feb. PMID 26332639
    2. DEN1 deneddylates non-cullin proteins in vivo. Chan Y, et al. J Cell Sci, 2008 Oct 1. PMID 18782863
    3. Neddylation activity modulates the neurodegeneration associated with fragile X associated tremor/ataxia syndrome (FXTAS) through regulating Sima. Lin Y, et al. Neurobiol Dis, 2020 Sep. PMID 32653676
    4. Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases. Broemer M, et al. Mol Cell, 2010 Dec 10. PMID 21145488
    5. Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination. Gao Y, et al. Mol Cell, 2022 Apr 7. PMID 35325613

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DEN1 regulates Cullin neddylation by suppressing CSN deneddylase activity.
      Title: Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster.
    2. Genetic analyses indicate that a balance between neddylation and deneddylation maintained by deneddylase 1 (DEN1) is crucial for animal viability.
      Title: DEN1 deneddylates non-cullin proteins in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deNEDDylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deNEDDylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deNEDDylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deneddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    deneddylase 1
    Names
    CG8493-PA
    CG8493-PC
    Den1-PA
    Den1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12337797..12339544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136919.3 → NP_610763.1  deneddylase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610763.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JUX2
      Related
      FBpp0087013
      Conserved Domains (1) summary
      cl23802
      Location:32 → 170
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. NM_001169655.2 → NP_001163126.1  deneddylase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV27, E1JH43
      Conserved Domains (1) summary
      cl23802
      Location:66 → 204
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JH43 E1JH43
    Q7JUX2 Q7JUX2

    Gene LinkOut

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