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    RN-tre Related to the N terminus of tre oncogene [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36554, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RN-treprovided by FlyBase
    Official Full Name
    Related to the N terminus of tre oncogeneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020620
    Locus tag
    Dmel_CG8085
    See related
    AllianceGenome:FB:FBgn0020620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13351; CG8085; Dmel\CG8085; DRN-tre
    Summary
    Predicted to enable GTPase activator activity. Predicted to be located in vesicle. Is expressed in organism. Orthologous to several human genes including USP6NL (USP6 N-terminal like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RN-tre in Genome Data Viewer
    Location:
    50C23-50C23; 2-68 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13984815..13990707, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9872320..9878212, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Chromosome transmission fidelity 4 Neighboring gene uncharacterized protein Neighboring gene mastermind Neighboring gene mir-4978 stem loop Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence and expression analysis of a Drosophila gene product related to the tre oncogene. Yedvobnick B, et al. Biochim Biophys Acta, 1998 Feb 11. PMID 9512660
    2. The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers. Smoller D, et al. Genes Dev, 1990 Oct. PMID 1701150
    3. The Drosophila melanogaster Rab GAP RN-tre cross-talks with the Rho1 signaling pathway to regulate nonmuscle myosin II localization and function. Platenkamp A, et al. Mol Biol Cell, 2020 Oct 1. PMID 32816624, Free PMC Article
    4. Rab-mediated vesicular transport is required for neuronal positioning in the developing Drosophila visual system. Houalla T, et al. Mol Brain, 2010 Jun 11. PMID 20540751, Free PMC Article
    5. Gain-of-function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development. Nicolaï M, et al. J Neurobiol, 2003 Dec. PMID 14608664

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_001188925.2
    • related to the N terminus of tre oncogene, isoform E
    NP_001260961.1
    • related to the N terminus of tre oncogene, isoform F
    NP_523736.1
    • related to the N terminus of tre oncogene, isoform B
    NP_652381.1
    • related to the N terminus of tre oncogene, isoform A
    NP_725351.1
    • related to the N terminus of tre oncogene, isoform C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13984815..13990707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166028.4 → NP_725351.1  uncharacterized protein Dmel_CG8085 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725351.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RE0
      Related
      FBpp0086729
      Conserved Domains (1) summary
      smart00164
      Location:100 → 315
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    2. NM_001274032.2 → NP_001260961.1  uncharacterized protein Dmel_CG8085 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260961.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEQ5
      Conserved Domains (1) summary
      smart00164
      Location:100 → 315
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    3. NM_001201996.3 → NP_001188925.2  uncharacterized protein Dmel_CG8085 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188925.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD18
      Conserved Domains (1) summary
      smart00164
      Location:100 → 315
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    4. NM_144124.4 → NP_652381.1  uncharacterized protein Dmel_CG8085 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652381.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9K4
      Related
      FBpp0086731
      Conserved Domains (1) summary
      smart00164
      Location:100 → 315
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    5. NM_079012.5 → NP_523736.1  uncharacterized protein Dmel_CG8085 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523736.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KQC4
      Related
      FBpp0086730
      Conserved Domains (1) summary
      smart00164
      Location:100 → 315
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD18 A0A0B4JD18
    A0A0B4KEQ5 A0A0B4KEQ5
    A1Z9K4 A1Z9K4
    Q5BI38 Q5BI38
    Q7KQC4 Q7KQC4
    Q95RE0 Q95RE0

    Gene LinkOut

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