U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CngA Cyclic nucleotide-gated ion channel subunit A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36806, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CngAprovided by FlyBase
    Official Full Name
    Cyclic nucleotide-gated ion channel subunit Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261612
    Locus tag
    Dmel_CG42701
    See related
    AllianceGenome:FB:FBgn0261612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15709; CG42701; CG7779; cng; Cng; CNG; cngA; dCNCalpha; dmCNGA; DmCNGA; DmCNGC; Dmel\CG42701
    Old locus tag
    Dmel_CG15709; Dmel_CG7779
    Summary
    Enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity. Involved in monoatomic cation transmembrane transport and response to hypoxia. Part of intracellular cyclic nucleotide activated cation channel complex. Human ortholog(s) of this gene implicated in achromatopsia 2; color blindness; retinitis pigmentosa; and retinitis pigmentosa 49. Orthologous to several human genes including CNGA1 (cyclic nucleotide gated channel subunit alpha 1) and CNGA2 (cyclic nucleotide gated channel subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CngA in Genome Data Viewer
    Location:
    53A1-53A2; 2-79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16243145..16259805, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12130650..12147310, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene krimper Neighboring gene uncharacterized protein Neighboring gene fidipidine Neighboring gene capsuleen

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Primary structure and functional expression of a Drosophila cyclic nucleotide-gated channel present in eyes and antennae. Baumann A, et al. EMBO J, 1994 Nov 1. PMID 7957070, Free PMC Article
    2. Molecular determinants of a Ca2+-binding site in the pore of cyclic nucleotide-gated channels: S5/S6 segments control affinity of intrapore glutamates. Seifert R, et al. EMBO J, 1999 Jan 4. PMID 9878056, Free PMC Article
    3. A single intracellular cysteine residue is responsible for the activation of the olfactory cyclic nucleotide-gated channel by NO. Broillet MC. J Biol Chem, 2000 May 19. PMID 10809749
    4. Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide-gated channels. Lam YL, et al. J Gen Physiol, 2015 Sep. PMID 26283200, Free PMC Article
    5. Probing the transmembrane topology of cyclic nucleotide-gated ion channels with a gene fusion approach. Henn DK, et al. Proc Natl Acad Sci U S A, 1995 Aug 1. PMID 7543681, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cGMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cAMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cGMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hypoxia IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intracellular cyclic nucleotide activated cation channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of intracellular cyclic nucleotide activated cation channel complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cyclic nucleotide-gated ion channel subunit A
    Names
    CG42701-PA
    CG42701-PB
    CNG channel alpha subunit
    CNG-channel
    CngA-PA
    CngA-PB
    Cyclic-nucleotide-gated ion channel protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16243145..16259805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202031.2 → NP_001188960.1  cyclic nucleotide-gated ion channel subunit A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCU4
      Conserved Domains (5) summary
      COG0664
      Location:598 → 722
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:604 → 717
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:309 → 529
      Ion_trans; Ion transport protein
      pfam07885
      Location:477 → 527
      Ion_trans_2; Ion channel
      pfam16526
      Location:720 → 791
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    2. NM_057768.3 → NP_477116.1  cyclic nucleotide-gated ion channel subunit A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24278, Q9V7L5
      Related
      FBpp0292050
      Conserved Domains (5) summary
      COG0664
      Location:423 → 547
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:429 → 542
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:134 → 354
      Ion_trans; Ion transport protein
      pfam07885
      Location:302 → 352
      Ion_trans_2; Ion channel
      pfam16526
      Location:545 → 616
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCU4 A0A0B4JCU4
    Q24278.2 Q24278
    Q3YNF6 Q3YNF6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous