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    Brca2 BRCA2, DNA repair associated [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37916, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Brca2provided by FlyBase
    Official Full Name
    BRCA2, DNA repair associatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050169
    Locus tag
    Dmel_CG30169
    See related
    AllianceGenome:FB:FBgn0050169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    30169; BcDNA:SD25109; brca; brca2; BRCA2; CG13583; CG13584; CG30169; dmbrca2; Dmbrca2; Dmel\CG30169
    Summary
    Involved in DNA synthesis involved in DNA repair; meiotic recombination checkpoint signaling; and response to camptothecin. Located in nucleus. Is expressed in organism. Used to study 46 XX gonadal dysgenesis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Brca2 in Genome Data Viewer
    Location:
    60D4-60D4; 2-107 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24526172..24529581)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20413695..20417104)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 60f Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 60e Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A fragmented alignment method detects a putative phosphorylation site and a putative BRC repeat in the Drosophila melanogaster BRCA2 protein. Chakraborty S. F1000Res, 2013. PMID 24627786, Free PMC Article
    2. Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2. Bennett SM, et al. PLoS One, 2010 Jun 8. PMID 20543987, Free PMC Article
    3. Essential Role of BRCA2 in Ovarian Development and Function. Weinberg-Shukron A, et al. N Engl J Med, 2018 Sep 13. PMID 30207912, Free PMC Article
    4. Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2. Thomas AM, et al. G3 (Bethesda), 2013 Jan. PMID 23316441, Free PMC Article
    5. Annealing of Complementary DNA Sequences During Double-Strand Break Repair in Drosophila Is Mediated by the Ortholog of SMARCAL1. Holsclaw JK, et al. Genetics, 2017 May. PMID 28258182, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. persistent meiotic DNA double-strand breaks might correspond to crossovers, which are mobilized to the nuclear envelope for their repair; Brca2-Pds5 complexes may be key mediators of this process.
      Title: Brca2-Pds5 complexes mobilize persistent meiotic recombination sites to the nuclear envelope.
    2. A mutation in Cyp6d2, a cytochrome P450 gene, when combined with a brca2 mutation, resulted in synergistic hypersensitivity to camptothecin.
      Title: Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2.
    3. DNA repair by homologous recombination is dramatically decreased in CG30169 (brca2 homolog) mutants.
      Title: Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA synthesis involved in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA repair synthesis involved in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic recombination checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic recombination checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to camptothecin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BRCA2, DNA repair associated
    Names
    Brca2-PA
    CG30169-PA
    breast cancer 2 early onset homolog
    breast cancer 2, early onset homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24526172..24529581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138081.4 → NP_611925.2  BRCA2, DNA repair associated [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611925.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2CPK7, B2CPK8, Q494G5, Q8MRU0, Q9W157
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W157.3 Q9W157

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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