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    RhoGEF3 Rho guanine nucleotide exchange factor 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoGEF3provided by FlyBase
    Official Full Name
    Rho guanine nucleotide exchange factor 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0264707
    Locus tag
    Dmel_CG43976
    See related
    AllianceGenome:FB:FBgn0264707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1225; CG13881; CG13882; CG13883; CG42377; CG42378; CG43976; Dmel\CG43976; DrhoGEF3; RhoGEF; rhoGEF3
    Old locus tag
    Dmel_CG1225; Dmel_CG13881; Dmel_CG13882; Dmel_CG13883; Dmel_CG42377; Dmel_CG42378
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in actin cytoskeleton organization; melanotic encapsulation of foreign target; and wound healing. Predicted to be active in cytosol. Is expressed in several structures, including anlage in statu nascendi; ganglia; gut section; head epidermis primordium; and organism subdivision. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 8. Orthologous to human ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9) and SPATA13 (spermatogenesis associated 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGEF3 in Genome Data Viewer
    Location:
    61B3-61C1; 3-1 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (277437..305292)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (277437..305292)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene midkine and pleiotrophin 2 Neighboring gene tiny tim 2 Neighboring gene four wheel drive Neighboring gene deadbeat Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern. Hicks MS, et al. Dev Genes Evol, 2001 May. PMID 11455443
    2. Regulation of cortical stability by RhoGEF3 in mitotic Sensory Organ Precursor cells in Drosophila. Couturier L, et al. Biol Open, 2017 Dec 15. PMID 29101098, Free PMC Article
    3. Calcium influx rapidly establishes distinct spatial recruitments of Annexins to cell wounds. Nakamura M, et al. Genetics, 2024 Aug 7. PMID 38874345, Free PMC Article
    4. Tissue-wide coordination of epithelium-to-neural stem cell transition in the Drosophila optic lobe requires Neuralized. Shard C, et al. J Cell Biol, 2020 Nov 2. PMID 32946560, Free PMC Article
    5. Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity. Sailem H, et al. Open Biol, 2014 Jan 22. PMID 24451547, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RhoGEF2, Pbl, RhoGEF3, and Tum exhibit discrete localization patterns and are required for cell wound repair.
      Title: Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 295290-295334 mobile_element_type = transposon:INE-1{}3917

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho guanine nucleotide exchange factor 3
    Names
    CG43976-PA
    CG43976-PB
    CG43976-PC
    CG43976-PE
    CG43976-PF
    CG43976-PG
    CG43976-PH
    CG43976-PJ
    CG43976-PK
    CG43976-PL
    CG43976-PM
    CG43976-PQ
    RhoGEF3-PA
    RhoGEF3-PB
    RhoGEF3-PC
    RhoGEF3-PE
    RhoGEF3-PF
    RhoGEF3-PG
    RhoGEF3-PH
    RhoGEF3-PJ
    RhoGEF3-PK
    RhoGEF3-PL
    RhoGEF3-PM
    RhoGEF3-PQ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      277437..305292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274273.1 → NP_001261202.1  Rho guanine nucleotide exchange factor 3, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261202.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBG8
      Conserved Domains (5) summary
      smart00326
      Location:2875 → 2941
      SH3; Src homology 3 domains
      cd01224
      Location:3239 → 3372
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:3284 → 3362
      PH; PH domain
      pfam00621
      Location:3030 → 3234
      RhoGEF; RhoGEF domain
      pfam16060
      Location:754 → 790
      DUF4802; Domain of unknown function (DUF4802)

    2. NM_138180.4 → NP_612024.4  Rho guanine nucleotide exchange factor 3, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612024.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0S2
      Conserved Domains (5) summary
      smart00326
      Location:2876 → 2942
      SH3; Src homology 3 domains
      cd01224
      Location:3240 → 3373
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:3285 → 3363
      PH; PH domain
      pfam00621
      Location:3031 → 3235
      RhoGEF; RhoGEF domain
      pfam16060
      Location:754 → 790
      DUF4802; Domain of unknown function (DUF4802)

    3. NM_138182.2 → NP_612026.2  Rho guanine nucleotide exchange factor 3, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612026.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTU9, Q9W0S0
      Conserved Domains (4) summary
      smart00326
      Location:383 → 449
      SH3; Src homology 3 domains
      cd01224
      Location:747 → 880
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:792 → 870
      PH; PH domain
      pfam00621
      Location:538 → 742
      RhoGEF; RhoGEF domain

    4. NM_138183.3 → NP_612027.2  Rho guanine nucleotide exchange factor 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612027.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTU9, Q9W0R9
      Conserved Domains (4) summary
      smart00326
      Location:368 → 434
      SH3; Src homology 3 domains
      cd01224
      Location:732 → 865
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:777 → 855
      PH; PH domain
      pfam00621
      Location:523 → 727
      RhoGEF; RhoGEF domain

    5. NM_001144390.2 → NP_001137862.1  Rho guanine nucleotide exchange factor 3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GTU9, Q9W0R9
      Conserved Domains (4) summary
      smart00326
      Location:368 → 434
      SH3; Src homology 3 domains
      cd01224
      Location:732 → 865
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:777 → 855
      PH; PH domain
      pfam00621
      Location:523 → 727
      RhoGEF; RhoGEF domain

    6. NM_001382119.1 → NP_001368935.1  Rho guanine nucleotide exchange factor 3, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6J3SKB4, Q6NLK9
      Conserved Domains (3) summary
      smart00326
      Location:328 → 394
      SH3; Src homology 3 domains
      cd00160
      Location:480 → 686
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01224
      Location:692 → 825
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    7. NM_167824.2 → NP_728516.1  Rho guanine nucleotide exchange factor 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728516.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLK9, Q8IRJ3
      Conserved Domains (4) summary
      smart00326
      Location:287 → 353
      SH3; Src homology 3 domains
      cd01224
      Location:651 → 784
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:696 → 774
      PH; PH domain
      pfam00621
      Location:442 → 646
      RhoGEF; RhoGEF domain

    8. NM_167825.2 → NP_728517.1  Rho guanine nucleotide exchange factor 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLK9, Q8IRJ2
      Conserved Domains (4) summary
      smart00326
      Location:282 → 348
      SH3; Src homology 3 domains
      cd01224
      Location:646 → 779
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:691 → 769
      PH; PH domain
      pfam00621
      Location:437 → 641
      RhoGEF; RhoGEF domain

    9. NM_167823.2 → NP_728515.1  Rho guanine nucleotide exchange factor 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728515.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLK9, Q8IRJ4
      Conserved Domains (4) summary
      smart00326
      Location:289 → 355
      SH3; Src homology 3 domains
      cd01224
      Location:653 → 786
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:698 → 776
      PH; PH domain
      pfam00621
      Location:444 → 648
      RhoGEF; RhoGEF domain

    10. NM_001169837.1 → NP_001163308.1  Rho guanine nucleotide exchange factor 3, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163308.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHV3, Q6NLK9
      Conserved Domains (4) summary
      smart00326
      Location:177 → 243
      SH3; Src homology 3 domains
      cd01224
      Location:541 → 674
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:586 → 664
      PH; PH domain
      pfam00621
      Location:332 → 536
      RhoGEF; RhoGEF domain

    11. NM_001169836.1 → NP_001163307.1  Rho guanine nucleotide exchange factor 3, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163307.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHV3, Q6NLK9
      Conserved Domains (4) summary
      smart00326
      Location:177 → 243
      SH3; Src homology 3 domains
      cd01224
      Location:541 → 674
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:586 → 664
      PH; PH domain
      pfam00621
      Location:332 → 536
      RhoGEF; RhoGEF domain

    12. NM_001144391.1 → NP_001137863.1  Rho guanine nucleotide exchange factor 3, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0H3, Q6NLK9
      Conserved Domains (4) summary
      smart00326
      Location:277 → 343
      SH3; Src homology 3 domains
      cd01224
      Location:641 → 774
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:686 → 764
      PH; PH domain
      pfam00621
      Location:432 → 636
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6J3SKB4 A0A6J3SKB4
    B7Z0H3 B7Z0H3
    E1JHV3 E1JHV3
    M9PBG8 M9PBG8
    Q8IRJ2 Q8IRJ2
    Q8IRJ3 Q8IRJ3
    Q8IRJ4 Q8IRJ4
    Q8MSB6 Q8MSB6
    Q9GTU9 Q9GTU9
    Q9W0R9 Q9W0R9
    Q9W0S0 Q9W0S0
    Q9W0S2 Q9W0S2

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