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    gry gryzun [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38391, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gryprovided by FlyBase
    Official Full Name
    gryzunprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286567
    Locus tag
    Dmel_CG17569
    See related
    AllianceGenome:FB:FBgn0286567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17569; Dmel\CG17569; gryz; l(3)63Bd; TRAPPC11
    Summary
    Involved in intracellular transport; long-term memory; and protein secretion. Located in Golgi apparatus. Part of TRAPPIII protein complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2S. Orthologous to human TRAPPC11 (trafficking protein particle complex subunit 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gry in Genome Data Viewer
    Location:
    63B11-63B13; 3-6 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3199090..3211348)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3199090..3211348)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Heat shock protein 83 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hobbit Neighboring gene ncRNA Neighboring gene neutral sphingomyelinase Neighboring gene Ribosomal protein L28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking. Portela M, et al. Glia, 2019 Feb. PMID 30506943
    2. Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition. Casas-Tintó S, et al. Nat Commun, 2015 Dec 11. PMID 26658841
    3. Parcas is the predominant Rab11-GEF for rhodopsin transport in Drosophila photoreceptors. Otsuka Y, et al. J Cell Sci, 2019 Aug 7. PMID 31296556
    4. SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum. Wang L, et al. Cell Rep, 2023 Jan 31. PMID 36848233, Free PMC Article
    5. Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1. Galindo A, et al. EMBO J, 2021 Jun 15. PMID 34018214, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 3200580-3200624 mobile_element_type = transposon:gypsy9{}4910

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPIII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gryzun
    Names
    CG17569-PB
    gry-PB
    lethal (3) 63Bd

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3199090..3211348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139528.3 → NP_647785.3  gryzun [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647785.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWD7, Q8IRE3
      Related
      FBpp0072906
      Conserved Domains (2) summary
      pfam11817
      Location:265 → 518
      Foie-gras_1; Foie gras liver health family 1
      pfam12742
      Location:1232 → 1275
      Gryzun-like; Gryzun, putative Golgi trafficking
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IG85 Q8IG85
    Q8IRE3 Q8IRE3
    Q960U6 Q960U6

    Gene LinkOut

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