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    nab nab [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346237, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nabprovided by FlyBase
    Official Full Name
    nabprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259986
    Locus tag
    Dmel_CG33545
    See related
    AllianceGenome:FB:FBgn0259986
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15000; CG15001; CG33545; Dmel\CG33545; dnab; dNAB; l(2)SH3 143; l(3)64Aj; l(3)SH143; l(3)SH21; Nab; NAB
    Summary
    Enables transcription coregulator activity. Involved in generation of neurons; locomotory behavior; and wing disc pattern formation. Predicted to be active in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; ganglia; imaginal disc; mushroom body; and somatic precursor cell. Orthologous to human NAB1 (NGFI-A binding protein 1) and NAB2 (NGFI-A binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nab in Genome Data Viewer
    Location:
    64A8-64A8; 3-10 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4153618..4160932, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4153618..4160932, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene masquerade Neighboring gene long non-coding RNA:CR44529

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A reverse genetic screen in Drosophila using a deletion-inducing mutagen. Nairz K, et al. Genome Biol, 2004. PMID 15461801, Free PMC Article
    2. Inverse regulation of target genes at the brink of the BMP morphogen activity gradient. Ziv O, et al. J Cell Sci, 2012 Dec 1. PMID 22956540
    3. Temporal Cohorts of Lineage-Related Neurons Perform Analogous Functions in Distinct Sensorimotor Circuits. Wreden CC, et al. Curr Biol, 2017 May 22. PMID 28502656
    4. Nab controls the activity of the zinc-finger transcription factors Squeeze and Rotund in Drosophila development. Terriente Félix J, et al. Development, 2007 May. PMID 17428824
    5. The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling. Ziv O, et al. Development, 2009 Apr. PMID 19270172

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings indicate that the NAB primary signal activates JNK, which in turn transmits two independent signals
      Title: The NAB-Brk signal bifurcates at JNK to independently induce apoptosis and compensatory proliferation.
    2. show that the products of the genes klumpfuss, nab and castor play important roles in their specification via a genetic cascade
      Title: A genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS.
    3. transcriptional co-regulator dNAB is a Dpp target in the developing wing that interacts with Brk to eliminate cells with reduced Dpp signaling through the JNK pathway
      Title: The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling.
    4. dnab RNA is expressed exclusively in a subset of neuroblasts in the embryonic and larval central nervous system (CNS), as well as in several larval imaginal disc tissues; role in CNS and eye development
      Title: Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development.
    5. Squeeze and Rotund are regulated by Nab and have roles in Drosophila development
      Title: Nab controls the activity of the zinc-finger transcription factors Squeeze and Rotund in Drosophila development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuroblast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nab
    Names
    CG33545-PB
    CG33545-PC
    CG33545-PD
    lethal (3) SH143
    nab-PB
    nab-PC
    nab-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4153618..4160932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014557.2 → NP_001014557.3  nab, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014557.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5X541, E1JIC7, Q59E55
      UniProtKB/TrEMBL
      H5V8C4
      Conserved Domains (2) summary
      pfam04904
      Location:113 → 190
      NCD1; NAB conserved region 1 (NCD1)
      pfam04905
      Location:301 → 435
      NCD2; NAB conserved region 2 (NCD2)

    2. NM_001274478.1 → NP_001261407.1  nab, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261407.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8C4, M9PBN9
      Conserved Domains (2) summary
      pfam04904
      Location:113 → 190
      NCD1; NAB conserved region 1 (NCD1)
      pfam04905
      Location:301 → 435
      NCD2; NAB conserved region 2 (NCD2)

    3. NM_001169873.1 → NP_001163344.1  nab, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163344.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8C4
      Conserved Domains (2) summary
      pfam04904
      Location:113 → 190
      NCD1; NAB conserved region 1 (NCD1)
      pfam04905
      Location:301 → 435
      NCD2; NAB conserved region 2 (NCD2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBN9 M9PBN9
    Q59E55.3 Q59E55

    Gene LinkOut

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