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    shep alan shepard [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38605, updated on 9-Dec-2024

    Summary

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    Official Symbol
    shepprovided by FlyBase
    Official Full Name
    alan shepardprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052423
    Locus tag
    Dmel_CG32423
    See related
    AllianceGenome:FB:FBgn0052423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alan; alan-shepard; anon-EST:Posey83; anon-WO0118547.198; anon-WO0172774.41; BcDNA:LD40028; BcDNA:RH63980; CG10647; CG10649; cg10668; CG10668; CG32423; Dmel\CG32423; Shep
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Involved in several processes, including female courtship behavior; gravitaxis; and neuron remodeling. Located in cytosol. Is expressed in several structures, including circulatory system primordium; ganglia; glial cell; larval neurons; and somatic precursor cell. Orthologous to human RBMS1 (RNA binding motif single stranded interacting protein 1); RBMS2 (RNA binding motif single stranded interacting protein 2); and RBMS3 (RNA binding motif single stranded interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See shep in Genome Data Viewer
    Location:
    64C7-64C11; 3-13 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5155821..5277944, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5148921..5271044, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Alanyl-tRNA synthetase, mitochondrial Neighboring gene Signal recognition particle 54k Neighboring gene XPG-like endonuclease Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45741 Neighboring gene long non-coding RNA:CR45742

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. metaseq: a Python package for integrative genome-wide analysis reveals relationships between chromatin insulators and associated nuclear mRNA. Dale RK, et al. Nucleic Acids Res, 2014 Aug. PMID 25063299, Free PMC Article
    2. The neurodevelopmental genes alan shepard and Neuroglian contribute to female mate preference in African Drosophila melanogaster. Roy PR, et al. J Evol Biol, 2024 Aug 1. PMID 38900077,
    3. Clustering of Drosophila housekeeping promoters facilitates their expression. Corrales M, et al. Genome Res, 2017 Jul. PMID 28420691, Free PMC Article
    4. Drosophila Shep and C. elegans SUP-26 are RNA-binding proteins that play diverse roles in nervous system development. Schachtner LT, et al. Dev Genes Evol, 2015 Nov. PMID 26271810
    5. Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling. Chen D, et al. Nat Commun, 2021 Nov 4. PMID 34737269, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA-binding capability of Shep is necessary to antagonize gypsy insulator activities and promote neuronal maturation.
      Title: Shep RNA-Binding Capacity Is Required for Antagonism of gypsy Chromatin Insulator Activity.
    2. results reveal direct regulation of transcriptional programs by Shep to regulate neuronal remodeling during metamorphosis.
      Title: Shep regulates Drosophila neuronal remodeling by controlling transcription of its chromatin targets.
    3. Data show that RNA binding proteins sup-26 and shep are required for the development of diverse cell types within the nematode and fly nervous systems during embryonic and larval stages.
      Title: Drosophila Shep and C. elegans SUP-26 are RNA-binding proteins that play diverse roles in nervous system development.
    4. Thus, shep regulates metamorphic growth of the bursicon neurons, and it may also serve as a general regulator of neuronal growth during metamorphic remodeling.
      Title: Neuronal remodeling during metamorphosis is regulated by the alan shepard (shep) gene in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gravitaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metamorphosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress HMP PubMed 
    involved_in response to gravity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alan shepard
    Names
    CG32423-PA
    CG32423-PB
    CG32423-PD
    CG32423-PE
    CG32423-PF
    CG32423-PG
    CG32423-PH
    CG32423-PI
    shep-PA
    shep-PB
    shep-PD
    shep-PE
    shep-PF
    shep-PG
    shep-PH
    shep-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5155821..5277944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168112.4 → NP_729055.1  alan shepard, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729055.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSV2
      Related
      FBpp0076877
      Conserved Domains (2) summary
      cd12243
      Location:136 → 204
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:224 → 302
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    2. NM_001274510.1 → NP_001261439.1  alan shepard, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261439.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSV2
      Conserved Domains (2) summary
      cd12243
      Location:21 → 91
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:109 → 187
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    3. NM_001259707.1 → NP_001246636.1  alan shepard, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246636.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JID7, M9ND50, M9PEP6, Q7KU60, Q86BS4, Q8MSV2, Q8SWY6, Q95S20, Q95S52, Q9VRK3, Q9VRK5
      Conserved Domains (2) summary
      cd12243
      Location:243 → 313
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:322 → 400
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    4. NM_168114.5 → NP_729057.3  alan shepard, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729057.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSV2
      Conserved Domains (2) summary
      cd12243
      Location:21 → 91
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:109 → 187
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    5. NM_168111.4 → NP_729054.3  alan shepard, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729054.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSV2
      Conserved Domains (2) summary
      cd12243
      Location:231 → 301
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:310 → 388
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    6. NM_168113.3 → NP_729056.1  alan shepard, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729056.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSV2
      Related
      FBpp0076876
      Conserved Domains (2) summary
      cd12243
      Location:136 → 204
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:224 → 302
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    7. NM_001274509.1 → NP_001261438.1  alan shepard, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261438.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSV2
      Conserved Domains (2) summary
      cd12243
      Location:21 → 91
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:111 → 189
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    8. NM_001169879.2 → NP_001163350.1  alan shepard, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSV2
      Conserved Domains (2) summary
      cd12243
      Location:21 → 91
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:111 → 189
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSV2.2 Q8MSV2

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