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    Dscam2 Down syndrome cell adhesion molecule 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38788, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dscam2provided by FlyBase
    Official Full Name
    Down syndrome cell adhesion molecule 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0265296
    Locus tag
    Dmel_CG42256
    See related
    AllianceGenome:FB:FBgn0265296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT03867; CG14828; CG17742; CG32387; CG32389; CG42256; CG8618; CG8619; CT14580; CT14584; CT34644; Dmel\CG42256; DSCAM; Dscam-like
    Old locus tag
    Dmel_CG32387; Dmel_CG32389
    Summary
    Enables identical protein binding activity. Involved in homophilic cell adhesion via plasma membrane adhesion molecules and neuron projection morphogenesis. Predicted to be active in axon and plasma membrane. Is expressed in adult head; eye disc; and spermatozoon. Orthologous to human DSCAM (DS cell adhesion molecule) and DSCAML1 (DS cell adhesion molecule like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dscam2 in Genome Data Viewer
    Location:
    65E6-65E7; 3-19 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7159199..7189931, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7152299..7183031, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene melted Neighboring gene cornetto Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45410 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dscam2 affects visual perception in Drosophila melanogaster. Bosch DS, et al. Front Behav Neurosci, 2015. PMID 26106310, Free PMC Article
    2. Cell-specific alternative splicing of Drosophila Dscam2 is crucial for proper neuronal wiring. Lah GJ, et al. Neuron, 2014 Sep 17. PMID 25175881
    3. Drosophila dscam proteins regulate postsynaptic specificity at multiple-contact synapses. Millard SS, et al. Neuron, 2010 Sep 9. PMID 20826308, Free PMC Article
    4. Drosophila larval motor patterning relies on regulated alternative splicing of Dscam2. Odierna GL, et al. Front Mol Neurosci, 2024. PMID 39092203, Free PMC Article
    5. Regulated Alternative Splicing of Drosophila Dscam2 Is Necessary for Attaining the Appropriate Number of Photoreceptor Synapses. Kerwin SK, et al. Genetics, 2018 Feb. PMID 29208630, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dscam2 suppresses synaptic strength through a PI3K-dependent endosomal pathway.
      Title: Dscam2 suppresses synaptic strength through a PI3K-dependent endosomal pathway.
    2. Mbl protein controls Dscam2 alternative splicing. Mbl represses Dscam2 isoform A and promotes the selection of isoform B.
      Title: Deterministic splicing of Dscam2 is regulated by Muscleblind.
    3. different combinations of Dscam proteins act through distinct mechanisms in closely related neurons to pattern neural circuits.
      Title: Dscam Proteins Direct Dendritic Targeting through Adhesion.
    4. cell-specific expression of two biochemically distinct alternative isoforms of Dscam2 prevents, L1 and L2 neurons from repelling each other
      Title: Cell-specific alternative splicing of Drosophila Dscam2 is crucial for proper neuronal wiring.
    5. the immunoglobulin superfamily member Dscam2 restricts the connections formed by L1 lamina neurons to columns in the Drosophila visual system
      Title: Dscam2 mediates axonal tiling in the Drosophila visual system.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    down syndrome cell adhesion molecule 2
    Names
    CG42256-PE
    CG42256-PF
    CG42256-PG
    CG42256-PH
    CG42256-PI
    CG42256-PJ
    CG42256-PK
    CG42256-PL
    CG42256-PM
    CG42256-PN
    CG42256-PO
    CG42256-PP
    CG42256-PQ
    CG42256-PR
    CG42256-PS
    Dscam2-PE
    Dscam2-PF
    Dscam2-PG
    Dscam2-PH
    Dscam2-PI
    Dscam2-PJ
    Dscam2-PK
    Dscam2-PL
    Dscam2-PM
    Dscam2-PN
    Dscam2-PO
    Dscam2-PP
    Dscam2-PQ
    Dscam2-PR
    Dscam2-PS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7159199..7189931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168196.4 → NP_729225.2  down syndrome cell adhesion molecule 2, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729225.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z0C6, B7Z0C7, B7Z0C8, Q0E8H6, Q8MTB2, Q9VS28, Q9VS29, Q9VS30
      Conserved Domains (6) summary
      cd00096
      Location:822 → 893
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:905 → 1000
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:724 → 801
      Ig; Immunoglobulin domain

    2. NM_001300035.1 → NP_001286964.1  down syndrome cell adhesion molecule 2, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286964.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXW7, X2JAR2
      Conserved Domains (6) summary
      cd00096
      Location:630 → 699
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:906 → 1001
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:725 → 802
      Ig; Immunoglobulin domain

    3. NM_001300036.1 → NP_001286965.1  down syndrome cell adhesion molecule 2, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286965.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXW9, X2JGC8
      Conserved Domains (6) summary
      cd00096
      Location:822 → 893
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:905 → 1000
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:724 → 801
      Ig; Immunoglobulin domain

    4. NM_168194.4 → NP_729223.2  down syndrome cell adhesion molecule 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729223.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VS29
      Conserved Domains (6) summary
      cd00096
      Location:822 → 893
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:905 → 1000
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:724 → 801
      Ig; Immunoglobulin domain

    5. NM_001274570.2 → NP_001261499.1  down syndrome cell adhesion molecule 2, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261499.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEU0
      Conserved Domains (6) summary
      cd00096
      Location:822 → 893
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:905 → 1005
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:724 → 801
      Ig; Immunoglobulin domain

    6. NM_001274569.2 → NP_001261498.1  down syndrome cell adhesion molecule 2, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261498.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PED2
      Conserved Domains (6) summary
      cd00096
      Location:630 → 699
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:906 → 1006
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:725 → 802
      Ig; Immunoglobulin domain

    7. NM_001274571.2 → NP_001261500.1  down syndrome cell adhesion molecule 2, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261500.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEK5
      Conserved Domains (6) summary
      cd00096
      Location:630 → 699
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:906 → 1006
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:725 → 802
      Ig; Immunoglobulin domain

    8. NM_001316478.1 → NP_001303407.1  down syndrome cell adhesion molecule 2, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WFE8
      Conserved Domains (6) summary
      cd00096
      Location:630 → 699
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:906 → 1006
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:725 → 802
      Ig; Immunoglobulin domain

    9. NM_001169896.3 → NP_001163367.1  down syndrome cell adhesion molecule 2, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163367.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXW7, E1JI62
      Conserved Domains (6) summary
      cd00096
      Location:630 → 699
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:906 → 1006
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:725 → 802
      Ig; Immunoglobulin domain

    10. NM_001043123.3 → NP_001036588.2  down syndrome cell adhesion molecule 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036588.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXW7
      Conserved Domains (6) summary
      cd00096
      Location:630 → 699
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:906 → 1001
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:725 → 802
      Ig; Immunoglobulin domain

    11. NM_001144424.2 → NP_001137896.1  down syndrome cell adhesion molecule 2, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXW9
      Conserved Domains (6) summary
      cd00096
      Location:822 → 893
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:905 → 1000
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:724 → 801
      Ig; Immunoglobulin domain

    12. NM_168195.3 → NP_729224.2  down syndrome cell adhesion molecule 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729224.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXW9
      Conserved Domains (6) summary
      cd00096
      Location:822 → 893
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:905 → 1000
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:724 → 801
      Ig; Immunoglobulin domain

    13. NM_001169897.2 → NP_001163368.1  down syndrome cell adhesion molecule 2, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163368.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXW9, E1JI61
      Conserved Domains (6) summary
      cd00096
      Location:822 → 893
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      cd00063
      Location:905 → 1005
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:724 → 801
      Ig; Immunoglobulin domain

    14. NM_001144426.2 → NP_001137898.1  down syndrome cell adhesion molecule 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137898.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4IJ57
      Conserved Domains (5) summary
      cd00096
      Location:632 → 699
      Ig; Immunoglobulin domain
      smart00408
      Location:533 → 597
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      pfam07679
      Location:521 → 610
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:247 → 327
      Ig; Immunoglobulin domain

    15. NM_001144425.2 → NP_001137897.1  down syndrome cell adhesion molecule 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8G2
      Conserved Domains (4) summary
      smart00408
      Location:436 → 507
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:432 → 517
      IG_like; Immunoglobulin like
      pfam07679
      Location:238 → 327
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:247 → 327
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WFE8 A0A0S0WFE8
    E1JI61 E1JI61
    E1JI62 E1JI62
    M9PED2 M9PED2
    M9PEK5 M9PEK5
    M9PEU0 M9PEU0
    Q9VS29.3 Q9VS29
    X2JAR2 X2JAR2
    X2JGC8 X2JGC8

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